ID K3ZVJ1_SETIT Unreviewed; 306 AA.
AC K3ZVJ1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Ubiquitin thioesterase OTU {ECO:0000256|RuleBase:RU367104};
DE EC=3.4.19.12 {ECO:0000256|RuleBase:RU367104};
GN Name=101758723 {ECO:0000313|EnsemblPlants:KQL25042};
GN ORFNames=SETIT_2G252800v2 {ECO:0000313|EMBL:RCV12226.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQL25042, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EMBL:RCV12226.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL25042,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV12226.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV12226.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV12226.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL25042}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL25042};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins
CC and may therefore play an important regulatory role at the level of
CC protein turnover by preventing degradation.
CC {ECO:0000256|RuleBase:RU367104}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|RuleBase:RU367104};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367104}.
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DR EMBL; AGNK02001172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003529; RCV12226.1; -; Genomic_DNA.
DR RefSeq; XP_004957176.1; XM_004957119.1.
DR RefSeq; XP_012698848.1; XM_012843394.1.
DR AlphaFoldDB; K3ZVJ1; -.
DR STRING; 4555.K3ZVJ1; -.
DR EnsemblPlants; KQL25042; KQL25042; SETIT_030622mg.
DR GeneID; 101758723; -.
DR Gramene; KQL25042; KQL25042; SETIT_030622mg.
DR KEGG; sita:101758723; -.
DR eggNOG; KOG2606; Eukaryota.
DR HOGENOM; CLU_046927_0_0_1; -.
DR InParanoid; K3ZVJ1; -.
DR OMA; RAISCHV; -.
DR OrthoDB; 1125427at2759; -.
DR Proteomes; UP000004995; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR CDD; cd22760; OTU_plant_OTU4-like; 1.
DR Gene3D; 3.90.70.80; -; 1.
DR InterPro; IPR047947; OTU4_OTU.
DR InterPro; IPR003323; OTU_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR PANTHER; PTHR13312; HIV-INDUCED PROTEIN-7-LIKE PROTEASE; 1.
DR PANTHER; PTHR13312:SF5; UBIQUITIN THIOESTERASE OTU; 1.
DR Pfam; PF02338; OTU; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50802; OTU; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|RuleBase:RU367104};
KW Hydrolase {ECO:0000256|RuleBase:RU367104};
KW Protease {ECO:0000256|RuleBase:RU367104};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Thiol protease {ECO:0000256|RuleBase:RU367104};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU367104}.
FT DOMAIN 159..281
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
SQ SEQUENCE 306 AA; 33904 MW; 4E28AC7E48D35704 CRC64;
MLLNTLSISW RCCTLWNMYS ESSQLPGRLT QRVDLWNTSC SQALRHHDRI GSVKKNINSS
HLQTTACFDS LGRQSQCRQP TRSHILNVKS DILSHHKFAT ISWRLGSMPR KIGGIASGQG
FAVSGMASAE GPVDNEVDST QPAESSANLS HGKKVYTDYS VTGIPGDGRC LFRSVAHGAC
IRSGKPIPSE DLQRKLADEL RTMVADEFIK RRAETEWFVE GDFDTYVSQI RKPHVWGGEP
ELFMASHVLQ MPITVYMHDK EAGGLIAIAE YGQEYGTEAP IQVLYHGCGH YEALQIPGKG
GPRSRL
//
