ID K4A6N7_SETIT Unreviewed; 677 AA.
AC K4A6N7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Thioredoxin domain-containing protein {ECO:0000259|PROSITE:PS51352};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQK88485, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EnsemblPlants:KQK88485, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQK88485,
RC ECO:0000313|Proteomes:UP000004995};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EnsemblPlants:KQK88485}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQK88485};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: May only reduce GSH-thiol disulfides, but not protein
CC disulfides. {ECO:0000256|ARBA:ARBA00002426}.
CC -!- SIMILARITY: Belongs to the glutaredoxin family. CGFS subfamily.
CC {ECO:0000256|ARBA:ARBA00008983}.
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DR EMBL; AGNK02005545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K4A6N7; -.
DR STRING; 4555.K4A6N7; -.
DR EnsemblPlants; KQK88485; KQK88485; SETIT_034542mg.
DR Gramene; KQK88485; KQK88485; SETIT_034542mg.
DR eggNOG; KOG0911; Eukaryota.
DR HOGENOM; CLU_026126_12_2_1; -.
DR InParanoid; K4A6N7; -.
DR OMA; HDIVMEL; -.
DR Proteomes; UP000004995; Chromosome IX.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IBA:GO_Central.
DR CDD; cd03028; GRX_PICOT_like; 3.
DR CDD; cd02984; TRX_PICOT; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 4.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR033658; GRX_PICOT-like.
DR InterPro; IPR004480; Monothiol_GRX-rel.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR NCBIfam; TIGR00365; Grx4 family monothiol glutaredoxin; 3.
DR PANTHER; PTHR10293; GLUTAREDOXIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10293:SF73; GLUTAREDOXIN-3; 1.
DR Pfam; PF00462; Glutaredoxin; 3.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 4.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 3.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995}.
FT DOMAIN 167..287
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 72555 MW; 453D47CCC9CACE73 CRC64;
MEVRNGSKAT GMPIERGGRD VATRVSAQAR ALTSCRRPSP FIGSSTGSEP RRRRLDPTAA
QQHTTSLCQA GGATTTRSTA HARPPKNAPD QAETSRNLTT LGCGCLSIEC LEATHPGSEL
APRCSARPTR SIDSIARPQS RGKPQAVTST PGVLHHRRLH PHLFFPSHPA KGGGAVQAMA
SGGAVREVGS KAELDAAVAG ARAAAVHFWA GWCEASKQMD EVFAHLAVDF PHAVFLRVEA
EEQPEISEAY GVSAVPYFVF CKEGKTVDTL EGANPASLAN KVAKIAGPAS VAESAVPASL
GVAAGPAVLE KVQELAQRNG SSADEGTNSV GLPDSLNKRL EQLVNSHPVF LFMKGTPEQP
RCGFSRKVVD ILKQEGVDFG SFDILTDNDV REGMKKFSNW PTFPQLYCKG ELLGGCDIVI
AMHDSGELKD VFEEHNIPLK PQGSKNVETV EPEAPTGKGG AVSEPVGLTD ALKARLESLV
NSSPVMVFIK GSPEELKCGF SGKLVHILKQ ENIPFSSFDI LADDDVRQGL KVFSNWPSYP
QLYIKGELVG GSDIVMEMHK SGELKKVLSE KGVIPKETLE DRLKALISSA PVMLFMKGTP
DAPRCGFSSK VVNALKNEGI SFGSFDILSD EEVRQGLKAY SNWPTFPQLY YKSELIGGCD
IILEMEKSGE LKSTLSE
//
