ID K4FWE2_GADMO Unreviewed; 578 AA.
AC K4FWE2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Toll-like receptor 23b {ECO:0000313|EMBL:AFK76498.1};
GN Name=tlr23b {ECO:0000313|EMBL:AFK76498.1};
OS Gadus morhua (Atlantic cod).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus.
OX NCBI_TaxID=8049 {ECO:0000313|EMBL:AFK76498.1};
RN [1] {ECO:0000313|EMBL:AFK76498.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23273344; DOI=10.1186/1471-2148-12-256;
RA Sundaram A.Y., Kiron V., Dopazo J., Fernandes J.M.;
RT "Diversification of the expanded teleost-specific toll-like receptor family
RT in Atlantic cod, Gadus morhua.";
RL BMC Evol. Biol. 12:256-256(2012).
RN [2] {ECO:0000313|EMBL:AFK76498.1}
RP NUCLEOTIDE SEQUENCE.
RA Sundaram A., Kiron V., Fernandes J.M.O.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; JX074785; AFK76498.1; -; mRNA.
DR AlphaFoldDB; K4FWE2; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AFK76498.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 382..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 432..573
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 578 AA; 67877 MW; B8A8FA1FB64F3B9F CRC64;
MKRLRRLGLR GNVLQKVPVV VNSLSSLEIL DLGFNDILEL GCSDFVNLTS LKELYLQYNY
IRKLKRCVFQ NQNVLKILSI NSNMLLELGG VFETRLQKLQ FLDMTRNEIP NFPNGSFKGL
ESLQHLYMDK LYTTVNVFDG LHNLRSLSVY LPFEMIRFKG LHELRNLTIY MGVPEGFNGT
YANNYKGLME LPSVRNITII CKSFHFEFPL YIPSYYLHKM RHLEHFTAVN FYIEEPHLDT
FMYAHNLKSL SIRASFLTGM SPEHFQAMSN LEVLDLSENA LRTLDFLEAN LTSLRCLIVS
QNELTVLNES VFQSLPALTY LDLSDNPLTC DCSNAGFLLW ALSSEQTQLT RGYNQPCTYP
LSEKRTMLLD FDVRSCWMDS NFLCFISTSS IVLFTLLASF SYHFLRWQLV YAYYLFMALL
YDMRERKNNE QHRYDAFISY NVKDEEWVHR EMLPALEDER GWKICLHHRD FQPGKPIIEN
ITEAIYSSRK TICVISRPYL ESEWCSREIQ MASFRLFDEN KDVLILLFME DLLDHQLSPY
YRMRKMVKKS TYLSWPKAGQ NTDVFWQNVH RALEKGQP
//
