ID K4GLS5_ALOAN Unreviewed; 167 AA.
AC K4GLS5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
GN Name=NTF3 {ECO:0000313|EMBL:AFM92998.1};
OS Alopoglossus angulatus (Spectacled lizard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC Teiioidea; Gymnophthalmidae; Alopoglossus.
OX NCBI_TaxID=979739 {ECO:0000313|EMBL:AFM92998.1};
RN [1] {ECO:0000313|EMBL:AFM92998.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22993238; DOI=10.1098/rsbl.2012.0703;
RA Wiens J.J., Hutter C.R., Mulcahy D.G., Noonan B.P., Townsend T.M.,
RA Sites J.W.Jr., Reeder T.W.;
RT "Resolving the phylogeny of lizards and snakes (Squamata) with extensive
RT sampling of genes and species.";
RL Biol. Lett. 8:1043-1046(2012).
RN [2] {ECO:0000313|EMBL:AFM92998.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22982760; DOI=10.1016/j.ympev.2012.08.018;
RA Mulcahy D.G., Noonan B.P., Moss T., Townsend T.M., Reeder T.W.,
RA Sites J.W.Jr., Wiens J.J.;
RT "Estimating divergence dates and evaluating dating methods using
RT phylogenomic and mitochondrial data in squamate reptiles.";
RL Mol. Phylogenet. Evol. 65:974-991(2012).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR EMBL; JN568329; AFM92998.1; -; Genomic_DNA.
DR AlphaFoldDB; K4GLS5; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 127..167
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFM92998.1"
FT NON_TER 167
FT /evidence="ECO:0000313|EMBL:AFM92998.1"
SQ SEQUENCE 167 AA; 18772 MW; 250F2C41CCF0A151 CRC64;
IQSTNMDQGN LPEDTINSLI IKLIQGDILK NKMSKQVTDD LQDSVKKTKA VELDTGGDDN
ANFDFQPLIA MDSELLRQQK HYSSPRVLLS DNIPLEPPPL YLMEDYIGNS VIVNRTSRHK
RFAENKSHRG EYSVCDSESR WVTDKSSAVD IRGHQVTVLG EIKMGPS
//
