ID K4HGY3_VAREA Unreviewed; 156 AA.
AC K4HGY3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Prostaglandin E receptor 4 {ECO:0000313|EMBL:AFR13680.1};
DE Flags: Fragment;
GN Name=PTGER4 {ECO:0000313|EMBL:AFR13680.1};
OS Varanus exanthematicus (Savannah monitor lizard) (Lacerta exanthematica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX NCBI_TaxID=8557 {ECO:0000313|EMBL:AFR13680.1};
RN [1] {ECO:0000313|EMBL:AFR13680.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22993238; DOI=10.1098/rsbl.2012.0703;
RA Wiens J.J., Hutter C.R., Mulcahy D.G., Noonan B.P., Townsend T.M.,
RA Sites J.W.Jr., Reeder T.W.;
RT "Resolving the phylogeny of lizards and snakes (Squamata) with extensive
RT sampling of genes and species.";
RL Biol. Lett. 8:1043-1046(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JN880627; AFR13680.1; -; Genomic_DNA.
DR AlphaFoldDB; K4HGY3; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004957; F:prostaglandin E receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001758; Prost_EP4_rcpt.
DR InterPro; IPR008365; Prostanoid_rcpt.
DR PANTHER; PTHR11866; G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER; 1.
DR PANTHER; PTHR11866:SF6; PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01788; PROSTANOIDR.
DR PRINTS; PR00586; PRSTNOIDEP4R.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AFR13680.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..156
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFR13680.1"
FT NON_TER 156
FT /evidence="ECO:0000313|EMBL:AFR13680.1"
SQ SEQUENCE 156 AA; 17466 MW; AE7AFE69BD8DE0E8 CRC64;
VVGNLIAIVV LCKSRKEQKE TTFYTLVCGL AVTDLLGTCL VSPVTIATYL KNEWPGGKPL
CEYSTFILLF FGLSGLSIIC AMSIERYLAI NHAYFYNHYV DKKLAALTLF AIYVSNVLFC
ALPSMGLGST KLQYPQTWCF IDWRTNVTTH AAYSYM
//
