ID K4IYB9_BURCE Unreviewed; 212 AA.
AC K4IYB9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 03-MAY-2023, entry version 30.
DE RecName: Full=Alkylmercury lyase {ECO:0000256|ARBA:ARBA00018180, ECO:0000256|HAMAP-Rule:MF_00714};
DE EC=4.99.1.2 {ECO:0000256|ARBA:ARBA00013237, ECO:0000256|HAMAP-Rule:MF_00714};
DE AltName: Full=Organomercurial lyase {ECO:0000256|ARBA:ARBA00031271, ECO:0000256|HAMAP-Rule:MF_00714};
GN Name=merB1 {ECO:0000313|EMBL:AFU75979.1};
GN Synonyms=merB {ECO:0000256|HAMAP-Rule:MF_00714};
OS Burkholderia cepacia (Pseudomonas cepacia).
OG Plasmid pIJB1 {ECO:0000313|EMBL:AFU75979.1}.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=292 {ECO:0000313|EMBL:AFU75979.1};
RN [1] {ECO:0000313|EMBL:AFU75979.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=2a {ECO:0000313|EMBL:AFU75979.1};
RC PLASMID=pIJB1 {ECO:0000313|EMBL:AFU75979.1};
RA Sebastianelli A., Bruce I.J.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFU75979.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=2a {ECO:0000313|EMBL:AFU75979.1};
RC PLASMID=pIJB1 {ECO:0000313|EMBL:AFU75979.1};
RA Lin Q.Y., Bruce I.J.;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cleaves the carbon-mercury bond of organomercurials such as
CC phenylmercuric acetate. One product is Hg(2+), which is subsequently
CC detoxified by the mercuric reductase. {ECO:0000256|ARBA:ARBA00025326,
CC ECO:0000256|HAMAP-Rule:MF_00714}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an alkylmercury + H(+) = an alkane + Hg(2+);
CC Xref=Rhea:RHEA:18777, ChEBI:CHEBI:15378, ChEBI:CHEBI:16793,
CC ChEBI:CHEBI:18310, ChEBI:CHEBI:83725; EC=4.99.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000165, ECO:0000256|HAMAP-
CC Rule:MF_00714};
CC -!- SIMILARITY: Belongs to the MerB family. {ECO:0000256|ARBA:ARBA00009443,
CC ECO:0000256|HAMAP-Rule:MF_00714}.
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DR EMBL; JX847411; AFU75979.1; -; Genomic_DNA.
DR RefSeq; WP_011405610.1; NC_019378.1.
DR RefSeq; YP_006965881.1; NC_019378.1.
DR AlphaFoldDB; K4IYB9; -.
DR GO; GO:0018836; F:alkylmercury lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046413; P:organomercury catabolic process; IEA:InterPro.
DR GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.410; -; 1.
DR HAMAP; MF_00714; MerB; 1.
DR InterPro; IPR004927; MerB.
DR InterPro; IPR024259; MerB_HTH_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF12324; HTH_15; 1.
DR Pfam; PF03243; MerB; 1.
DR PIRSF; PIRSF001458; MerB; 1.
DR PRINTS; PR01699; ORGNOHGLYASE.
DR SUPFAM; SSF160387; NosL/MerB-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00714};
KW Mercuric resistance {ECO:0000256|ARBA:ARBA00022466, ECO:0000256|HAMAP-
KW Rule:MF_00714};
KW Mercury {ECO:0000256|ARBA:ARBA00022914, ECO:0000256|HAMAP-Rule:MF_00714};
KW Plasmid {ECO:0000313|EMBL:AFU75979.1}.
FT DOMAIN 7..78
FT /note="Alkylmercury lyase helix-turn-helix"
FT /evidence="ECO:0000259|Pfam:PF12324"
SQ SEQUENCE 212 AA; 22848 MW; 15EE9C9DCEA459F3 CRC64;
MDKTIYSKKI AESLSSGNHP KEFATLFVAL LRQLAMGGPV SREKLAGALG WSGARVATVL
EQAPGTEYDD EANIIGLGLT LRETSHVFEV DGRHLYTWCA LDTLMFPALT GKIARVTSRC
AATGRPITLT VAPEAVLHVE PAEAMVSLRT PDTSPDIRCS FCCHVHFFAS PSIANSWAST
HQGIEVVPVE SAFDLGHDVA LKLLEDCEES PV
//
