ID K5BFQ5_MYCHD Unreviewed; 765 AA.
AC K5BFQ5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Dimethyl sulfoxide/trimethylamine N-oxide reductase {ECO:0000313|EMBL:VCT90649.1};
DE EC=1.7.2.3 {ECO:0000313|EMBL:VCT90649.1};
DE SubName: Full=Molybdopterin guanine dinucleotide-containing S/N-oxide reductases family protein {ECO:0000313|EMBL:EKF24112.1};
GN Name=dmsA {ECO:0000313|EMBL:VCT90649.1};
GN ORFNames=C731_1872 {ECO:0000313|EMBL:EKF24112.1}, MHAS_02358
GN {ECO:0000313|EMBL:VCT90649.1};
OS Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 /
OS 3849) (Mycobacterium hassiacum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1122247 {ECO:0000313|EMBL:EKF24112.1, ECO:0000313|Proteomes:UP000006265};
RN [1] {ECO:0000313|EMBL:EKF24112.1, ECO:0000313|Proteomes:UP000006265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 {ECO:0000313|EMBL:EKF24112.1}, and DSM 44199 / CIP
RC 105218 / JCM 12690 / 3849 {ECO:0000313|Proteomes:UP000006265};
RX PubMed=23209251; DOI=10.1128/JB.01880-12;
RA Tiago I., Maranha A., Mendes V., Alarico S., Moynihan P.J., Clarke A.J.,
RA Macedo-Ribeiro S., Pereira P.J., Empadinhas N.;
RT "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of
RT heat-stable mycobacterial proteins.";
RL J. Bacteriol. 194:7010-7011(2012).
RN [2] {ECO:0000313|EMBL:VCT90649.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mhassiacum {ECO:0000313|EMBL:VCT90649.1};
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000268660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 / CIP 105218 / JCM 12690 / 3849
RC {ECO:0000313|Proteomes:UP000268660};
RX PubMed=30701245; DOI=10.1128/mra.01522-18;
RA Sanchez M., Blesa A., Sacristan-Horcajada E., Berenguer J.;
RT "Complete genome sequence of Mycolicibacterium hassiacum DSM 44199.";
RL Microbiol. Resour. Announc. 8:e01522-e01522(2019).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
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DR EMBL; AMRA01000046; EKF24112.1; -; Genomic_DNA.
DR EMBL; LR026975; VCT90649.1; -; Genomic_DNA.
DR RefSeq; WP_005626840.1; NZ_LR026975.1.
DR AlphaFoldDB; K5BFQ5; -.
DR STRING; 1122247.GCA_000379865_04775; -.
DR KEGG; mhas:MHAS_02358; -.
DR PATRIC; fig|1122247.3.peg.1802; -.
DR eggNOG; COG0243; Bacteria.
DR OrthoDB; 7376058at2; -.
DR Proteomes; UP000006265; Unassembled WGS sequence.
DR Proteomes; UP000268660; Chromosome 1.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0050626; F:trimethylamine-N-oxide reductase (cytochrome c) activity; IEA:UniProtKB-EC.
DR GO; GO:0009033; F:trimethylamine-N-oxide reductase activity; IEA:UniProtKB-EC.
DR CDD; cd02793; MopB_CT_DMSOR-BSOR-TMAOR; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR Gene3D; 3.90.55.10; Dimethylsulfoxide Reductase, domain 3; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR006658; BisC.
DR InterPro; IPR041954; CT_DMSOR/BSOR/TMAOR.
DR InterPro; IPR041460; Molybdopterin_N.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR NCBIfam; TIGR00509; bisC_fam; 1.
DR PANTHER; PTHR43742; TRIMETHYLAMINE-N-OXIDE REDUCTASE; 1.
DR PANTHER; PTHR43742:SF10; TRIMETHYLAMINE-N-OXIDE REDUCTASE 2; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF18364; Molybdopterin_N; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000313|EMBL:VCT90649.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006265}.
FT DOMAIN 7..46
FT /note="Molybdopterin oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18364"
FT DOMAIN 50..504
FT /note="Molybdopterin oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00384"
FT DOMAIN 616..730
FT /note="Molybdopterin dinucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF01568"
FT REGION 746..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 84311 MW; 1D83DC81AB7E9B4F CRC64;
MAAAKTSLTH WGAFRARVAD GDIAAVAPVH TSDPSPLLGN LVGSVRHRSR VTTPAVRRGW
LRDGPGPTDR RGADEFVPVS WDYLTELLAD ELRRVIDTHG NEAIYGGSYG WASAGRFHHA
QSQVHRFLNC IGGYTFSRHS YSLGATGVIM PRVVGTHDNL FKRSTEWQVI VENTDLLVCF
GGLALKNTAV NDGGTTAHPA RDALQRFRAR GGRIVSFSPL RDDVDGECEW YAPIPGTDVA
IMLALAHVLA TEGLLDRDFL DTYCTGYDRF ERYLLGRDDG VPKSPGWAEP ICGVPADDLV
RLARRMAAGR TLVTVSWSLQ RTRYGEQAPW MGVTLAAMLG QIGLPGGGFG HGYGSMNEPG
LAPLRCRLPS LPQGVNPVRT FIPVAAISDM LLRPGEQFDY NGLRLTYPDI RLVYWAGGNP
FHHHQNIPRL RRALARVDTV VVHDPYWTPM AKHADIVVPS TTAYERDDFS GSHTDPLLVA
MPALTEPYAQ ARDDYSTFAA LAERMGVGER FTEGRTAWQW LRHLYRTWAE QLDFEVPTFD
EFWRRGHLRL PTQTGLTLFA DFRADPQRHR LNTPSGRIEI FSADIDGFGY PDCAGHPKWY
EPPEWLRGPR AARYPLVLLA NQPATRLHSQ LDGGATSQAS KVQGREPMRM NPKDAAVRGL
VDGDVVRVFN DRGACLAGVV IDERVRENVV QLSTGAWYDP ADPADPDAMC VHGNPNVLTD
DSGTSSLAHG CTGAHTLVQV EKFVGEPPPV RAHEPPVLVS EPDAR
//
