ID K5BHP9_MYCHD Unreviewed; 321 AA.
AC K5BHP9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=2-haloacrylate reductase {ECO:0000313|EMBL:VCT92422.1};
DE EC=1.3.1.103 {ECO:0000313|EMBL:VCT92422.1};
DE SubName: Full=Zinc-binding dehydrogenase family protein {ECO:0000313|EMBL:EKF25872.1};
GN ORFNames=C731_0104 {ECO:0000313|EMBL:EKF25872.1}, MHAS_04149
GN {ECO:0000313|EMBL:VCT92422.1};
OS Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 /
OS 3849) (Mycobacterium hassiacum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1122247 {ECO:0000313|EMBL:EKF25872.1, ECO:0000313|Proteomes:UP000006265};
RN [1] {ECO:0000313|EMBL:EKF25872.1, ECO:0000313|Proteomes:UP000006265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 {ECO:0000313|EMBL:EKF25872.1}, and DSM 44199 / CIP
RC 105218 / JCM 12690 / 3849 {ECO:0000313|Proteomes:UP000006265};
RX PubMed=23209251; DOI=10.1128/JB.01880-12;
RA Tiago I., Maranha A., Mendes V., Alarico S., Moynihan P.J., Clarke A.J.,
RA Macedo-Ribeiro S., Pereira P.J., Empadinhas N.;
RT "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of
RT heat-stable mycobacterial proteins.";
RL J. Bacteriol. 194:7010-7011(2012).
RN [2] {ECO:0000313|EMBL:VCT92422.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mhassiacum {ECO:0000313|EMBL:VCT92422.1};
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000268660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 / CIP 105218 / JCM 12690 / 3849
RC {ECO:0000313|Proteomes:UP000268660};
RX PubMed=30701245; DOI=10.1128/mra.01522-18;
RA Sanchez M., Blesa A., Sacristan-Horcajada E., Berenguer J.;
RT "Complete genome sequence of Mycolicibacterium hassiacum DSM 44199.";
RL Microbiol. Resour. Announc. 8:e01522-e01522(2019).
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DR EMBL; AMRA01000005; EKF25872.1; -; Genomic_DNA.
DR EMBL; LR026975; VCT92422.1; -; Genomic_DNA.
DR RefSeq; WP_005623279.1; NZ_LR026975.1.
DR AlphaFoldDB; K5BHP9; -.
DR STRING; 1122247.GCA_000379865_03692; -.
DR KEGG; mhas:MHAS_04149; -.
DR PATRIC; fig|1122247.3.peg.94; -.
DR eggNOG; COG0604; Bacteria.
DR OrthoDB; 4190732at2; -.
DR Proteomes; UP000006265; Unassembled WGS sequence.
DR Proteomes; UP000268660; Chromosome 1.
DR GO; GO:0102523; F:2-chloroacrylate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08241; QOR1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR PANTHER; PTHR43677:SF3; PROSTAGLANDIN REDUCTASE 3; 1.
DR PANTHER; PTHR43677; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:VCT92422.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006265}.
FT DOMAIN 10..319
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 321 AA; 33247 MW; BBA0E8CC8E59C3D6 CRC64;
MKALVARELS GPAGLEFTDV DDVGGDNVVV VDVGAAGVSF PDLLLLRGEY QMRLDPPFIP
GMEVAGVVRS APEESEFTPG QRVTALCMLG GWAERVAVAP ESVSPTPDHL DDAEAVALLG
NYQTAYFALA RRGALRPGET VLVLGSAGGV GTASIQVAKA LGATVIALVH RTHAIDYVKS
LGADVVLPLT DGWLQQVRDA TGGRGVDLVV DPIGGPAFDD AIRALAVEGR LLVLGFASGG
GIPTVKVNRL LLRNVAVVGV GLGEFIRVRP ESASLFEFGV SELVKAGLRP PPPVRYPLAK
GAEALQSLAD GEVLGKVVLE P
//
