ID   K5WGQ2_PHACS            Unreviewed;       949 AA.
AC   K5WGQ2;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=PHACADRAFT_140069 {ECO:0000313|EMBL:EKM58279.1};
OS   Phanerochaete carnosa (strain HHB-10118-sp) (White-rot fungus) (Peniophora
OS   carnosa).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Phanerochaetaceae; Phanerochaete.
OX   NCBI_TaxID=650164 {ECO:0000313|EMBL:EKM58279.1, ECO:0000313|Proteomes:UP000008370};
RN   [1] {ECO:0000313|EMBL:EKM58279.1, ECO:0000313|Proteomes:UP000008370}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HHB-10118-sp {ECO:0000313|EMBL:EKM58279.1,
RC   ECO:0000313|Proteomes:UP000008370};
RX   PubMed=22937793; DOI=10.1186/1471-2164-13-444;
RA   Suzuki H., MacDonald J., Syed K., Salamov A., Hori C., Aerts A.,
RA   Henrissat B., Wiebenga A., vanKuyk P.A., Barry K., Lindquist E.,
RA   LaButti K., Lapidus A., Lucas S., Coutinho P., Gong Y., Samejima M.,
RA   Mahadevan R., Abou-Zaid M., de Vries R.P., Igarashi K., Yadav J.S.,
RA   Grigoriev I.V., Master E.R.;
RT   "Comparative genomics of the white-rot fungi, Phanerochaete carnosa and P.
RT   chrysosporium, to elucidate the genetic basis of the distinct wood types
RT   they colonize.";
RL   BMC Genomics 13:444-444(2012).
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DR   EMBL; JH930470; EKM58279.1; -; Genomic_DNA.
DR   RefSeq; XP_007393600.1; XM_007393538.1.
DR   AlphaFoldDB; K5WGQ2; -.
DR   STRING; 650164.K5WGQ2; -.
DR   GeneID; 18908479; -.
DR   KEGG; pco:PHACADRAFT_140069; -.
DR   HOGENOM; CLU_005275_0_0_1; -.
DR   InParanoid; K5WGQ2; -.
DR   OrthoDB; 5100844at2759; -.
DR   Proteomes; UP000008370; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041675; PH_5.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF15405; PH_5; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00036; CNH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008370}.
FT   DOMAIN          192..389
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          424..558
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          596..904
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EKM58279.1"
SQ   SEQUENCE   949 AA;  106719 MW;  90EEA1FFEC8E56FD CRC64;
     MSPRPHPHVA IPPGAAPPSR SSSRHVEDIN FIVTPADDSL WSEEYRHSTY IPSFPEPEIP
     RSPGRPASIH EAGGLGSYGY TDSPVYMSPT AKTASLRHSA SYQTLGHRIS MSESTLSARP
     PLHRGESRPP SYIESSPELP SNDLSDELSS LTLDSNEGLR RFQAGELGEN DEEWHRLVPK
     SALDTLDKHE VQRQSVIFEI IRSERDYVRD LELVRDVFVD PLVNTRPIPQ QRLKGYVTEV
     FYNLDDILGY HKSMLEKLFE LQRDQHPFIT NFASIILDIL IYSCTTASFA FRTAYEQYIK
     HYPLSEAYHR KELKRNSKYQ YFLSQCGQDP RIRKRDLITF LSRPVTRLPR LLLLVNTTQK
     HTPADHTDQE TLTLLVSLLS DFIKSTQPGI EAAESKVKFW ELCESMSFQK GEVVDLDLYD
     ESRTLQYSGP LARRYTSRTE VTYTWVDLHV ALLDNYLLLL KPEIRSNGST RHNVISRPIP
     LEYLRLATFD TLPENRREKA TSTIEQARLF DSFRSRHRPM YPFTIYHASA TLTRRYTLYA
     TSESERELWR RAMVDAIGIR KARQDANMWY APDTVDDSFF RLSNGLASHI SSSRITGKIR
     SATSFMIEGR TVIAAGCSSG IYIAARGKPD FKRVLKKANV AYLEALSSLN KIIVHSDDGL
     EAYSLDAMAL VGLGTARPQD LDASRERVSE QHAAIILARV VKISGRIIVL YATKSFMQVT
     LNALEAVATT DLTANLRRSI SSGSASFRSF GEPTWIPKDS HDIVALHKTI GVCAERGIHV
     FDPTNASGAN ATVIPNFSDA NEPMQLLKQR SSSAKPLGLV KVASNELLIV FDELGCYIDR
     HGVPCRSSGY LRWETKATSC AHRGEHVLLF SPEFIEIRSL ATGKLVQVIE GSDIRLVHAS
     ERGIFVAMHG DDKGGGGPND RLVELIETAD LTAQQQTSNV PGVWDEWDM
//