ID K5WHJ5_AGABU Unreviewed; 463 AA.
AC K5WHJ5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Lariat debranching enzyme C-terminal domain-containing protein {ECO:0000259|SMART:SM01124};
GN ORFNames=AGABI1DRAFT_123560 {ECO:0000313|EMBL:EKM74736.1};
OS Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC
OS 10392) (White button mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Agaricus.
OX NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM74736.1, ECO:0000313|Proteomes:UP000008493};
RN [1] {ECO:0000313|Proteomes:UP000008493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC {ECO:0000313|Proteomes:UP000008493};
RX PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V., Nagy L.G.,
RA Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L., Bailey A.M.,
RA Billette C., Coutinho P.M., Deakin G., Doddapaneni H., Floudas D.,
RA Grimwood J., Hilden K., Kuees U., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lucas S.M., Murat C., Riley R.W., Salamov A.A., Schmutz J., Subramanian V.,
RA Woesten H.A.B., Xu J., Eastwood D.C., Foster G.D., Sonnenberg A.S.,
RA Cullen D., de Vries R.P., Lundell T., Hibbett D.S., Henrissat B.,
RA Burton K.S., Kerrigan R.W., Challen M.P., Grigoriev I.V., Martin F.;
RT "Genome sequence of the button mushroom Agaricus bisporus reveals
RT mechanisms governing adaptation to a humic-rich ecological niche.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the lariat debranching enzyme family.
CC {ECO:0000256|ARBA:ARBA00006045}.
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DR EMBL; JH971429; EKM74736.1; -; Genomic_DNA.
DR RefSeq; XP_007334625.1; XM_007334563.1.
DR AlphaFoldDB; K5WHJ5; -.
DR STRING; 597362.K5WHJ5; -.
DR GeneID; 18826012; -.
DR KEGG; abp:AGABI1DRAFT123560; -.
DR eggNOG; KOG2863; Eukaryota.
DR HOGENOM; CLU_005893_1_0_1; -.
DR InParanoid; K5WHJ5; -.
DR OMA; AVIGCCH; -.
DR OrthoDB; 1220605at2759; -.
DR Proteomes; UP000008493; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008419; F:RNA lariat debranching enzyme activity; IEA:UniProt.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR CDD; cd00844; MPP_Dbr1_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR007708; DBR1_C.
DR InterPro; IPR041816; Dbr1_N.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR12849:SF0; LARIAT DEBRANCHING ENZYME; 1.
DR PANTHER; PTHR12849; RNA LARIAT DEBRANCHING ENZYME; 1.
DR Pfam; PF05011; DBR1; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SMART; SM01124; DBR1; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Reference proteome {ECO:0000313|Proteomes:UP000008493};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 301..451
FT /note="Lariat debranching enzyme C-terminal"
FT /evidence="ECO:0000259|SMART:SM01124"
SQ SEQUENCE 463 AA; 51581 MW; 55E4913D7ACB3704 CRC64;
MKIAVEGCCH GELEAIYDHT RDLENQNQYK VDLLLICGDF EATRNLADLQ CMAIPDKYKQ
LGGFYKYYTG EKSAPILTIA IGGNHEASNY MWELYHGGWL APNIYFLGHA GCVRVNGFSI
AGASGIFKPY DFRKGNFERL PYSPDSLRSI YHIREFNVLR LSLLSQPTIF LSHEWPQFIE
RFGDLKSLLE NKPQFQKSLD KGDFNSPPMM GLLKNLKPNW WFSAHLHIRF EADFVHEAVG
EPEFSEGRGG KVTSLDANIG NTEIEVKAIV AEGSATSTTS TPAVVAVAKE NPDPPPALAV
SQSQRSVTHF IGLDKCLPGR QFLEVVDIPT PRQGATSNGI SRVPVLEFNP EWLAITRAFH
PWFATTLRQR RFPIEREARS AVASATQWVF ENLQSESLLV DDIQQFVQTA PGPVAPASPN
QTVDEGVPQP PAYLNPQTEA FCRMIGIENK INPRGLSRGG DSQ
//
