ID K5WXX5_AGABU Unreviewed; 1630 AA.
AC K5WXX5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Histone deacetylase interacting domain-containing protein {ECO:0000259|SMART:SM00761};
GN ORFNames=AGABI1DRAFT_46078 {ECO:0000313|EMBL:EKM75658.1};
OS Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC
OS 10392) (White button mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Agaricus.
OX NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM75658.1, ECO:0000313|Proteomes:UP000008493};
RN [1] {ECO:0000313|Proteomes:UP000008493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC {ECO:0000313|Proteomes:UP000008493};
RX PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V., Nagy L.G.,
RA Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L., Bailey A.M.,
RA Billette C., Coutinho P.M., Deakin G., Doddapaneni H., Floudas D.,
RA Grimwood J., Hilden K., Kuees U., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lucas S.M., Murat C., Riley R.W., Salamov A.A., Schmutz J., Subramanian V.,
RA Woesten H.A.B., Xu J., Eastwood D.C., Foster G.D., Sonnenberg A.S.,
RA Cullen D., de Vries R.P., Lundell T., Hibbett D.S., Henrissat B.,
RA Burton K.S., Kerrigan R.W., Challen M.P., Grigoriev I.V., Martin F.;
RT "Genome sequence of the button mushroom Agaricus bisporus reveals
RT mechanisms governing adaptation to a humic-rich ecological niche.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00810}.
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DR EMBL; JH971410; EKM75658.1; -; Genomic_DNA.
DR RefSeq; XP_007333674.1; XM_007333612.1.
DR STRING; 597362.K5WXX5; -.
DR GeneID; 18829626; -.
DR KEGG; abp:AGABI1DRAFT46078; -.
DR eggNOG; KOG0069; Eukaryota.
DR eggNOG; KOG4204; Eukaryota.
DR HOGENOM; CLU_001360_2_2_1; -.
DR InParanoid; K5WXX5; -.
DR OMA; GRFQTWL; -.
DR OrthoDB; 199155at2759; -.
DR Proteomes; UP000008493; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 1.20.1160.11; Paired amphipathic helix; 3.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR013194; HDAC_interact_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003822; PAH.
DR InterPro; IPR036600; PAH_sf.
DR InterPro; IPR039774; Sin3-like.
DR InterPro; IPR031693; Sin3_C.
DR PANTHER; PTHR12346:SF0; SIN3A, ISOFORM G; 1.
DR PANTHER; PTHR12346; SIN3B-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR Pfam; PF02671; PAH; 3.
DR Pfam; PF08295; Sin3_corepress; 1.
DR Pfam; PF16879; Sin3a_C; 1.
DR SMART; SM00761; HDAC_interact; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF47762; PAH2 domain; 3.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
DR PROSITE; PS51477; PAH; 2.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00810}; Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008493}.
FT DOMAIN 876..975
FT /note="Histone deacetylase interacting"
FT /evidence="ECO:0000259|SMART:SM00761"
FT REGION 378..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1222..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1574..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1582..1601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1630 AA; 182896 MW; C44E1C4D2087461E CRC64;
MSKPASFVQP IPNSNAQTNR LTTINSHLRN LPKIVVTRDL GPEASALIQP KDSFEIIQWS
ENRACGRDWI LKNVPGAVAL VVTVVDKILT LVLVAGSNLK IVSTMSVGYE HLDVQAILSR
GIRIGYTPEV LTDAVADICV MLALMAGRNV RETMHIVDDG KWPSFGWAPF LFCGPQLGAS
PVSPRRTAGF IGFGRIAQAT LTRLIPFGIT DCIYSKSSGS KPDLDRDEAL RKTMGLQSLR
CVDLDELARE SDAVFVLAPG GAPTYHVVNE EFLRKMKKTA ILVNGARGSL VDSDALAKAL
REKWIWGAGV DVVEGEPHIT PDHPLVRERR CAVLPHIASA TTETRVGMAT LAIENMMAVL
TGKPIPKELL PHKLAGPAAV LSSSPPSTPM DTDDSKQMAL DDVPPGLPHP SRGPSPSRLG
TPRRHPDQVT ASESTYTAGE KDVEMGRPSA APPDIPPNPS DPQPSIAMLV DDPQSSRRQS
PIDPQSYPSI DRPLNVTDAL SYLDAVKIQF HDQPDVYNQF LDIMKEFKNE LIDTPGVIKR
VSQLFNGHSA LIQGFNTFLP VGYRIECSTD ANDSSYITVT TPTGTMMQTT NNGPGRGPIF
GTYDGRAIEP AVQYVQKIKN RCDPETYRQF LDILSRYHHK PETIDEEEVS RQIARLFKDA
PDLRADFRVF MPEQSRQLLD ESPPRTSPRT GTPLNEARNK RKLDAVASSM SLPPKRKRRA
PEKETVPSKP AQVVAVSMKI PPSAERTTLG YGNKNIAGPS SPHMVHSQLP PGPRPPLPVD
ETHFFERVKR ALDSRDTYNE FLKVVNLFTQ DFIDTARLVK ESKHFLGDGD LYRQFRDILG
WDELKEREYF MAEFQNNWTK PTPVQLPSRV SRIDPSVKYG SYRRLSASEA NVLCTGRDEM
CRSVLNDEWV SHPTWSSEDS GFISHKKNIY EEALHRSEEE RHEYDFHIEA ITRTISLLEP
LHHKIAQLSA EDRANFKLKP HIGGSWKPIH TRVIKKIYGR DLGLEVISSM QDSPVLAIPV
VLKRLKQKED EWKRSQREWN KVWREVDARN YTKSLDHQSI IFKTMDKKAI TTKALVNQIE
GAREEQMAKR ASLIDPLFAR TRQRHQLEYV IDDIRIVQDA LKLTFSFLDR TQGQINFAER
KRIEGFLRSF VPLFFILDPV TFNTAFLIHE TNESDGSEDI TDDVETSSVA SGSRNSSRSR
RGGNISNGGD LRKKLLKSEQ AKLTGRKTRA QEAAASPAVS RLASPALEND DSAAQAAIAN
KRKRNIFFTN TTFYALLRLI ELLYSRLYSF RDLATKLGKE KPDQKFPTKE AISAGMANQA
HDAIANFGER AKNPETFYEL LLVSCERLFD NEIEQHAFED QMRFMFGIKE AHRIFNVDKV
IGAIIKQVQA IVSDTRSQEL LENLKRERSV ASFTSQDQIN SRRSAEKILG PDENLFRVDW
LSDSKMMTIQ LIGKDDSSFD DAEVLTGRWQ AYIDSYVSSE NTAGVSQTRV RYPYLRRNIP
AKVRDIQPEA VTQDGQEIKV CVRTYRLFFV PGKEDFLWKV RSKEEMEEAA ANLTKRNILR
KQWLEKLRMT PAAFPKSPVR TDKTPTPLSS TTSNITGPPA VTETESEPKG ITAESIPPPH
QPPVAETTTV
//
