ID K5X3U0_AGABU Unreviewed; 1621 AA.
AC K5X3U0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=AGABI1DRAFT_117967 {ECO:0000313|EMBL:EKM82506.1};
OS Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC
OS 10392) (White button mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Agaricus.
OX NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM82506.1, ECO:0000313|Proteomes:UP000008493};
RN [1] {ECO:0000313|Proteomes:UP000008493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC {ECO:0000313|Proteomes:UP000008493};
RX PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V., Nagy L.G.,
RA Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L., Bailey A.M.,
RA Billette C., Coutinho P.M., Deakin G., Doddapaneni H., Floudas D.,
RA Grimwood J., Hilden K., Kuees U., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lucas S.M., Murat C., Riley R.W., Salamov A.A., Schmutz J., Subramanian V.,
RA Woesten H.A.B., Xu J., Eastwood D.C., Foster G.D., Sonnenberg A.S.,
RA Cullen D., de Vries R.P., Lundell T., Hibbett D.S., Henrissat B.,
RA Burton K.S., Kerrigan R.W., Challen M.P., Grigoriev I.V., Martin F.;
RT "Genome sequence of the button mushroom Agaricus bisporus reveals
RT mechanisms governing adaptation to a humic-rich ecological niche.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; JH971386; EKM82506.1; -; Genomic_DNA.
DR RefSeq; XP_007326502.1; XM_007326440.1.
DR STRING; 597362.K5X3U0; -.
DR GeneID; 18825389; -.
DR KEGG; abp:AGABI1DRAFT117967; -.
DR eggNOG; KOG0902; Eukaryota.
DR HOGENOM; CLU_000893_0_0_1; -.
DR InParanoid; K5X3U0; -.
DR OMA; TIEVWQS; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000008493; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000008493};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1038..1224
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1325..1603
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1621 AA; 183688 MW; DF9E44FE26F893F8 CRC64;
MEIEPTIDTY AWETMSESLK LASVCCVASG ELDEKVLSRT TLLLSPDSPI SDNLVQEAAL
KATAILVRSF PEITVTMTSH LRRFVTSPLP LFEFEFSSEG RAPPLAAAAK CLALCIQLAP
GDDFVMSNMY SLLNFIAATS KDTHDSSLVD GDAFDPSTLS SLETGLRELS EDEKRLTGIS
TISVVTRLAL EFSIEEVTKL TISMLLQRLR SAEPTVEAAI AYNLVDLALI APHASFIEII
RSFSAINRSA NPDDPRFSNN MVLAAQTRLA QDLNQRPELY EIYLTELLTL FLDKGVAIQN
LRVANPRVKI DDMVEQLASL LLPIDALVVH RDFKSWESAT PEVVALFRNL WFLCVLFNFT
TMEDSEANAM DWLRPALTRL ATKTPPMVIE EFQDAFASDI EYNTVIRQEY ADSVILKQRL
RLTKYLTLRS SDLRTLSTGQ VIFLLAMHDI ESMRALEGLP SSLVTYFIND SLNRNNVLIA
CMEGIAEQVI RGCQTALTVK ASQQALPKRL SQELRKLVIS STHRIANARE IASKYLNRLL
MSFPSLMCDP QLVYAILEVL TLLQRATENE YLDEHESTWE YHSERANITL QLTDNYQIRN
EILINLSRNA NSWFELALGR APLELQSTLQ KYLAVNQSVT GADSAELGAS IAEQFGKGVG
PVHRHLFSLK SLSRWNMDQS KILTSQIAIR SYYSGEAAGL GLAGREYNKL VQSDATPNAD
LYALHEKLKL TLKDIRSKRS KLTVQELRRL LYRCAAVLMS LSRCDYNLLH YLVVLPFAVA
TPSALVVAVE IWSWFISEKS ALEVALMSEI VSAWAGTIQH RKGIFRKHLN YQDPFSSPIS
YAPTDKDSMD KDLLAARRVL SPHVLVLHFL YSRLQAARYY QPNVMFLIRQ LVVHSAQSYK
RISTHALARE PRFSFLLFGF EALKSSHLDA YCENLMRESL YKMALSWYGV RPQWTYGADR
AQLEADIKVL SEFLSHLQSD AIRGLQPISS LSLLQSTSRA ARNLNKSLRL LTESELFRLH
VWNNPTNDVK RPADFIGATE RGLFDTVWLN IIRTVWGVDP AIAVFLTERF KSPFARNEVG
RLVRSSPKDV LGVPEAVFFL LGDRFDTSVR RDLRYLVLWA PVPPIIANTF FEIRYNNQAQ
ILQYAHRVLE EHPVDLTFFF IPQVVQALRC DAFGYVSQFI FETAKISQLF CHQIIWNMKA
NCYRDDVAGI EDPMKPTLDK MTDIVVKSLS GEAREFYDRE FNFFNEVTSI SGKLKPYIKK
TKLEKKAKID EEMAKIQVDA GVYLPSNPDG VVVDIDKKSG RPLQSHAKAP FMATFKVRKE
RIVIETNPDS VVDGAETEKR VECDVWQQAI FKVGDDCRQD VLALQVIAMF KNIFTNIGLP
LYLYPYRVTA TAPGCGVIDV VPNATSRDEM GRAKVNDLLD FFVTKYGGQD TVAFQKARLN
FIQSMAAYSV ACYLLQIKDR HNGNIMIDGE GHIVHIDFGF LFDIDKSKIF FSQFRHMTNS
SQGVKFEPHS FKLNHEMVVL MGGRYSQGYQ LFQSLTVKAF LAIRPFTEQI IDTVQLMLGT
EFPSFKGENT IRRFRDRFAQ QMNDRQAAEF MMSIVRNAHE NVRSTAYDEF QRLQNGIPYK
S
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