ID   K6WM66_9MICO            Unreviewed;       493 AA.
AC   K6WM66;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   SubName: Full=Cardiolipin synthetase {ECO:0000313|EMBL:GAB94871.1};
GN   Name=cls {ECO:0000313|EMBL:GAB94871.1};
GN   ORFNames=KILIM_014_00060 {ECO:0000313|EMBL:GAB94871.1};
OS   Kineosphaera limosa NBRC 100340.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermatophilaceae;
OC   Kineosphaera.
OX   NCBI_TaxID=1184609 {ECO:0000313|EMBL:GAB94871.1, ECO:0000313|Proteomes:UP000008366};
RN   [1] {ECO:0000313|EMBL:GAB94871.1, ECO:0000313|Proteomes:UP000008366}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 100340 {ECO:0000313|EMBL:GAB94871.1,
RC   ECO:0000313|Proteomes:UP000008366};
RA   Yoshida I., Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Ando Y.,
RA   Ohji S., Hamada M., Tamura T., Yamazoe A., Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Kineosphaera limosa NBRC 100340.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB94871.1}.
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DR   EMBL; BAHD01000014; GAB94871.1; -; Genomic_DNA.
DR   RefSeq; WP_006591403.1; NZ_BAHD01000014.1.
DR   AlphaFoldDB; K6WM66; -.
DR   STRING; 1184609.KILIM_014_00060; -.
DR   eggNOG; COG1502; Bacteria.
DR   OrthoDB; 9762009at2; -.
DR   Proteomes; UP000008366; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR   InterPro; IPR022924; Cardiolipin_synthase.
DR   InterPro; IPR027379; CLS_N.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR   PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR   PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR   Pfam; PF13091; PLDc_2; 2.
DR   Pfam; PF13396; PLDc_N; 1.
DR   SMART; SM00155; PLDc; 2.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008366};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        41..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          219..246
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
FT   DOMAIN          406..433
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
SQ   SEQUENCE   493 AA;  54908 MW;  5F9F0767B9A3DD60 CRC64;
     MFDVELPLFV ETVVLVVDFT IKALAIGIVP ENRRPSSSSA WLLLILFLPL VGLPLFLLLG
     SSRVNNRRHR IQAQANALLD DGLAHLPTVP PGLELPPGVE SMMALNRRLT SLPCVPGTVE
     EVLTDYHGML ADIAAAIDGA TRYVHVQTYI ARWDEASDPV FAAMARARAR GVEVRLLIDH
     LGSRRYRGYR RTKKRFKEAG FTWHLMLPID LLRLRWRRLD LRNHRKVIVV DGRLGYVGSL
     NLIAPHYGTD VPGGTKREWL ETVVRVSGPI VASLESVFAV DWYTECAELL DAQTYLPEAG
     SSPDLAIGGP VNALQVVPSG PGFQTQPNQR LFTSLIHRAQ RELLIVSPYF VPDESILEAV
     TTAAHRGVRV ELFVSERADQ FVVQHAQASY YTVLLEAGVR IHRYPAPFVL HAKFLTVDDE
     VAVIGSSNMD MRSFGLNYEI SLMGAAGDMP ARLRRIAAAY RGPSAELSLA DWETRPWLRR
     YTENVARLTS ALQ
//