ID K7BCL4_PANTR Unreviewed; 956 AA.
AC K7BCL4; A0A2J8PM68;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Matrilin 2 {ECO:0000313|EMBL:JAA04397.1, ECO:0000313|Ensembl:ENSPTRP00000072796.1};
GN Name=MATN2 {ECO:0000313|EMBL:JAA04397.1,
GN ECO:0000313|Ensembl:ENSPTRP00000072796.1,
GN ECO:0000313|VGNC:VGNC:13177};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA04397.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000072796.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA04397.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA04397.1}, and Skin
RC {ECO:0000313|EMBL:JAA24896.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000072796.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AACZ04067711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04067712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04067713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04067714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04067715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04067716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01006941; JAA04397.1; -; mRNA.
DR EMBL; GABD01008204; JAA24896.1; -; mRNA.
DR RefSeq; XP_003311906.1; XM_003311858.4.
DR STRING; 9598.ENSPTRP00000072796; -.
DR PaxDb; 9598-ENSPTRP00000034969; -.
DR Ensembl; ENSPTRT00000107205.1; ENSPTRP00000072796.1; ENSPTRG00000020451.6.
DR GeneID; 472939; -.
DR KEGG; ptr:472939; -.
DR CTD; 4147; -.
DR VGNC; VGNC:13177; MATN2.
DR GeneTree; ENSGT00940000158008; -.
DR OrthoDB; 1453590at2759; -.
DR Proteomes; UP000002277; Chromosome 8.
DR Bgee; ENSPTRG00000020451; Expressed in colon and 21 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0120216; C:matrilin complex; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR GO; GO:0031104; P:dendrite regeneration; IEA:Ensembl.
DR GO; GO:0008347; P:glial cell migration; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0048678; P:response to axon injury; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd01475; vWA_Matrilin; 2.
DR Gene3D; 1.20.5.30; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036337; Matrilin_cc_sf.
DR InterPro; IPR019466; Matrilin_coiled-coil_trimer.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF35; MATRILIN-2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 8.
DR Pfam; PF10393; Matrilin_ccoil; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 10.
DR SMART; SM01279; Matrilin_ccoil; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF58002; Chicken cartilage matrix protein; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..956
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015095829"
FT DOMAIN 57..236
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 361..401
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 655..830
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 840..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 925..952
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 956 AA; 106907 MW; A5F3E46A3BB72172 CRC64;
MEKMLAGCFL LILGQILLLP AEPRERSRGR SISRGRHART HPQTALLESS CENKRADLVF
IIDSSRSVNT HDYAKVKEFI VDILQFLDIG PDVTRVGLLQ YGSTVKNEFS LKTFKRKSEV
ERAVKRMRHL STGTMTGLAI QYALNIAFSE AEGARPLREN VPRVIMIVTD GRPQDSVAEV
AAKARDTGIL IFAIGVGQVD FNTLKSIGSE PHEDHVFLVA NFSQIETLTS VFQKKLCTAH
MCSTLEHNCA HFCINIPGSY ICRCKQGYIL NSDQTTCRIQ DLCAMEDHNC EQLCVNVPGS
FVCQCYSGYA LAEDGKRCVA VDYCASENHG CEHECVNADG SYLCQCHEGF ALNPDKKTCT
KIDYCASSNH GCQHECVNTD DSYSCHCLKG FTLNPDKKTC RRINYCALNK PGCEHECVNT
EESYYCRCHR GYTLDPNGKT CSRVDHCAQQ DHGCEQLCLN TEDSFVCQCS EGFLINEDLK
TCSRVDYCLL SDHGCEYSCV NMDRSFACQC PEGHVLRSDG KTCAKLDSCA LGDHGCEHSC
VSSEDSFVCQ CFEGYILRED GKTCRRKDVC QAIDHGCEHI CVNSDDSYTC ECLEGFQLAE
DGKRCRRKDV CKSTHHGCEH ICVNNGNSYI CKCSEGFVLA EDGRRCKKCT EGPIDLVFVI
DGSKSLGEEN FEVVKQFVTG IIDSLTISPK AARVGLLQYS TQVRTEFTLR NFNSAKDMKK
AVAHMKYMGK GSMTGLALKH MFERSFTQGE GARPLSTRVP RAAIVFTDGR AQDDVSEWAS
KAKANGITMY AVGVGKAIEE ELQEIASEPT NKHLFYAEDF STMDEISEKL KKGICEALED
SDGRQDSPAG ELPKRVQQPT ESEPVTINIQ DLLSCSNFAV QHRYLFEEDN LLRSTQKLSH
STKPSGSPLE EKHDQCKCEN LIMFQNLANE EVRKLTQRLE EMTQRMEALE NRLRYR
//
