ID K7C959_PANTR Unreviewed; 716 AA.
AC K7C959;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=EPS8-like 2 {ECO:0000313|EMBL:JAA15442.1};
GN Name=EPS8L2 {ECO:0000313|EMBL:JAA15442.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA15442.1};
RN [1] {ECO:0000313|EMBL:JAA15442.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAA23674.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA15442.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
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DR EMBL; GABF01006703; JAA15442.1; -; mRNA.
DR EMBL; GABD01009426; JAA23674.1; -; mRNA.
DR RefSeq; XP_016775509.1; XM_016920020.1.
DR AlphaFoldDB; K7C959; -.
DR GeneID; 450932; -.
DR KEGG; ptr:450932; -.
DR CTD; 64787; -.
DR OrthoDB; 2997036at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd09540; SAM_EPS8-like; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF20; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 493..552
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 182..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 716 AA; 80765 MW; 6D3F23301A03E053 CRC64;
MSQSGAVSCC PGATNGSLGR SDGVAKMSPK DLFEQRKKYS NSNVIMHETS QYHVQHLATF
IMDKSEAITS VDDAIRKLVQ LSSKEKIWTQ EMLLQVNDQS LRLLDIESQE ELENFPLPTV
QRSQTVLNQL RYPSVLLLVC QDSEQSKPDV HFFHCDEVEA ELVHEDIESA LADCRLGKKM
RPQTLKGHQE KIRQRQSILP PPQGPAPIPF QHRGGDSPEA KNRVGPQVPL SEPGFRRRES
QEEEPRAVLA QKIEKETQIL NCALDDIEWF VARLQKAAEA FKQLNQRKKG KKKGKKAPAE
GVLTLRARPP SEGEFIDCFQ KIKLAINLLA KLQKHIQNPS AAELVHFLFG PLELIVNTCS
GPDIARSVSY PLLSRDAVDF LRGHLVPKEM SLWESLGESW MRPRSEWPRE PQVPLYVPKF
HSGWEPPVDV LQEAPWEVEG LASAPIEEVS PVSRQSIRNS QKHSPTSEPT PPGDALPPVS
SPHTHRGYQP TPAMAKYVKI LYDFTARNAN ELSVLKDEVL EVLEDGRQWW KLRSRSGQAG
YVPCNILGEA RPEDAGAPFE QAGQKYWGAA SPTHKLPPSF PGNKDELMQH MDEVNDELIR
KISNIRAQPQ RHFRVERSQP VSQPLTYESG PDEVRAWLEA KAFSPRIVEN LGILTGPQLF
SLNKEELKKV CGEEGVRVYS QLTVQKAFLE KQQSGSELEE LMNKFHSMNQ RRGEDS
//
