ID K7CH03_PANTR Unreviewed; 1118 AA.
AC K7CH03; A0A2J8QPR4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Pleckstrin homology domain containing A5 {ECO:0000313|Ensembl:ENSPTRP00000093494.1};
DE SubName: Full=Pleckstrin homology domain containing, family A member 5 {ECO:0000313|EMBL:JAA31738.1};
GN Name=PLEKHA5 {ECO:0000313|EMBL:JAA31738.1,
GN ECO:0000313|Ensembl:ENSPTRP00000093494.1,
GN ECO:0000313|VGNC:VGNC:57774};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA31738.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000093494.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA31738.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA10086.1}, Skeletal muscle
RC {ECO:0000313|EMBL:JAA36687.1}, Skin {ECO:0000313|EMBL:JAA31738.1}, and
RC Smooth vascular {ECO:0000313|EMBL:JAA13146.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000093494.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AACZ04031255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04031256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AACZ04031257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01001252; JAA10086.1; -; mRNA.
DR EMBL; GABF01008999; JAA13146.1; -; mRNA.
DR EMBL; GABD01001362; JAA31738.1; -; mRNA.
DR EMBL; GABE01008052; JAA36687.1; -; mRNA.
DR RefSeq; XP_016778538.1; XM_016923049.1.
DR Ensembl; ENSPTRT00000085030.1; ENSPTRP00000093494.1; ENSPTRG00000050442.1.
DR GeneID; 465325; -.
DR CTD; 54477; -.
DR VGNC; VGNC:57774; PLEKHA5.
DR GeneTree; ENSGT00940000155728; -.
DR OrthoDB; 4609983at2759; -.
DR Proteomes; UP000002277; Chromosome 12.
DR Bgee; ENSPTRG00000050442; Expressed in temporal lobe and 21 other cell types or tissues.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR12752:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 5; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002277}.
FT DOMAIN 10..43
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 56..89
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 169..268
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 140..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..981
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1064
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1118 AA; 127721 MW; 2616C6EBCA3072F7 CRC64;
MAADLNLEWI SLPRSWTYGI TRGGRVFFIN EEAKSTTWLH PVTGEAVVTG HRRQSTDLPT
GWEEAYTFEG ARYYINHNER KVTCKHPVTG QPSQDNCIFV VNEQTVATMT SEEKKERPIS
MINEASNYNV TSDYAVHPMS PVGRTSRASK KVHNFGKRSN SIKRNPNAPV VRRGWLYKQD
STGMKLWKKR WFVLSDLCLF YYRDEKEEGI LGSILLPSFQ IALLTSEDHI NRKYAFKAAH
PNMRTYYFCT DTGKEMELWM KAMLDAALVQ TEPVKRVDKI TSENAPTKET NNIPNHRVLI
KPEIQNNQKN KEMSKIEEKK ALEAEKYGFQ KDGQDRPLTK INSVKLNSLP SEYESGSACP
AQTAHYRPIN LSSSENKIVN VSLADLRGGN RPNTGPLYTE ADRVIQRTNS MQQLEQWIKI
QKGRGHEEET RGVISYQTLP RNMPSHRAQI MARYPEGYRT LPRNSKTRPE SICSVTPSTH
DKTLGPGAEE KRRSMRDDTM WQLYEWQQRQ FYNKQSTLPR HSTLSSPKTM VNISDQTMHS
IPTSPSHGSI AAYQGYSPQR TYRSEVSSPI QRGDVTIDRR HRAHHPKHVY VPDRRSVPAG
LTLQSVSPQS LQGKTLSQDE GRGTLYKYRP EEVDIDAKLS RLCEQDKVVH ALEEKLQQLH
KEKYTLEQAL LSASQEIEMH ADNPAAIQTV VLQRDDLQNG LLSTCRELSR ATAELERAWR
EYDKLEYDVT VTRNQMQEQL DHLGEVQTES AGIQRAQIQK ELWRIQDVME GLSKHKQQRG
TTEIGMIGSK PFSTVKYKNE GPDYRLYKSE PELTTVAEVD ESNGEEKSEP VSEIETSVVK
GSHFPVGVVP PRAKSPTPES STIASYVTLR KTKKMMDLRT ERPRSAVEQL CLAESTRPRM
TVEEQMERIR RHQQACLREK KKGLNVIGAS DQSPLQSPSN LRDNPFRTTQ TRRRDDNVKE
LDTAIRENDV KPDHETPATE IVQLKETEPQ NVDFSKELKK TENISYEMLF EPEPNGVNSV
EMMDKERNKE KMPEDVTYSP QDETQITNHK PEEHPEENTK NSVDEQEETV ISYESTPEVS
RGNQTMAVKS LSPSPESSAS PVPSTQPQLT EGSHFMCV
//
