ID K7D1G7_PANTR Unreviewed; 461 AA.
AC K7D1G7; A0A2J8JVZ4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Ribonuclease inhibitor {ECO:0000256|ARBA:ARBA00014554};
DE AltName: Full=Ribonuclease/angiogenin inhibitor 1 {ECO:0000256|ARBA:ARBA00032534};
GN Name=RNH1 {ECO:0000313|EMBL:JAA31310.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA31310.1};
RN [1] {ECO:0000313|EMBL:JAA31310.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skin {ECO:0000313|EMBL:JAA31310.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA16768.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG.
CC May play a role in redox homeostasis. {ECO:0000256|ARBA:ARBA00025561}.
CC -!- SUBUNIT: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
CC {ECO:0000256|ARBA:ARBA00011699}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GABF01005377; JAA16768.1; -; mRNA.
DR EMBL; GABF01005376; JAA16769.1; -; mRNA.
DR EMBL; GABF01005375; JAA16770.1; -; mRNA.
DR EMBL; GABF01005374; JAA16771.1; -; mRNA.
DR EMBL; GABF01005373; JAA16772.1; -; mRNA.
DR EMBL; GABD01001793; JAA31307.1; -; mRNA.
DR EMBL; GABD01001792; JAA31308.1; -; mRNA.
DR EMBL; GABD01001791; JAA31309.1; -; mRNA.
DR EMBL; GABD01001790; JAA31310.1; -; mRNA.
DR RefSeq; NP_001009060.1; NM_001009060.1.
DR RefSeq; XP_016775242.1; XM_016919753.1.
DR RefSeq; XP_016775243.1; XM_016919754.1.
DR RefSeq; XP_016775244.1; XM_016919755.1.
DR RefSeq; XP_016775245.1; XM_016919756.1.
DR RefSeq; XP_016775246.1; XM_016919757.1.
DR RefSeq; XP_016775247.1; XM_016919758.1.
DR RefSeq; XP_016775248.1; XM_016919759.1.
DR RefSeq; XP_016775249.1; XM_016919760.1.
DR RefSeq; XP_016775250.1; XM_016919761.1.
DR AlphaFoldDB; K7D1G7; -.
DR SMR; K7D1G7; -.
DR GeneID; 450154; -.
DR KEGG; ptr:450154; -.
DR CTD; 6050; -.
DR OMA; CQLECLW; -.
DR OrthoDB; 55870at2759; -.
DR GO; GO:0032311; C:angiogenin-PRI complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0008428; F:ribonuclease inhibitor activity; IEA:Ensembl.
DR GO; GO:0045765; P:regulation of angiogenesis; IEA:Ensembl.
DR CDD; cd00116; LRR_RI; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR041302; LRR_RI_cap.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF13516; LRR_6; 6.
DR Pfam; PF18779; LRR_RI_capping; 1.
DR SMART; SM00367; LRR_CC; 5.
DR SMART; SM00368; LRR_RI; 13.
DR SUPFAM; SSF52047; RNI-like; 2.
PE 2: Evidence at transcript level;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
SQ SEQUENCE 461 AA; 49929 MW; 5C41BECC53ECA693 CRC64;
MSLDIQSLDI QCEELSDARW AELLPLLQQC QVVRLDDCGL TEARCKDISS ALRVNPALAE
LNLRSNELGD VGVHCVLQGL QSPSCKIQKL SLQNCCLTGA GCGVLSSTLR TLPTLQELHL
SDNLLGDAGL QLLCEGLLDP QCRLEKLQLE YCNLSAASCK PLASVLRAKP DFKELTVSNN
DINEAGVRVL CQGLKDSPCQ LEALKLESCG VTSDNCRDLC GIVASKASLR ELALGSNKLG
DVGMAELCPG LLHPSSRLRT LWIWECGITA KGCGDLCRVL RAKESLKELS LAGNELGDEG
ARLLCETLLE PGCQLESLWV KSCSFTAACC SHFSSVLAQN KFLLELQISN NRLEDAGVQE
LCQGLGQPGS VLRVLWLADC DVSDSSCSSL AATLLANHSL RELDLSNNCL GDAGILQLVE
SVRQPGCLLE QLVLYDIYWS EEMEDRLQAL EKDKPSLRVI S
//
