ID K7E125_MONDO Unreviewed; 1055 AA.
AC K7E125;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Aryl hydrocarbon receptor-like {ECO:0000313|Ensembl:ENSMODP00000039476.1};
GN Name=LOC100011653 {ECO:0000313|Ensembl:ENSMODP00000039476.1};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000039476.1, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000039476.1, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000039476.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007486117.1; XM_007486055.2.
DR AlphaFoldDB; K7E125; -.
DR STRING; 13616.ENSMODP00000039476; -.
DR Ensembl; ENSMODT00000042582.2; ENSMODP00000039476.1; ENSMODG00000028175.2.
DR GeneID; 100011653; -.
DR KEGG; mdo:100011653; -.
DR eggNOG; KOG3560; Eukaryota.
DR GeneTree; ENSGT00940000154486; -.
DR HOGENOM; CLU_289660_0_0_1; -.
DR InParanoid; K7E125; -.
DR OMA; QEHYWHS; -.
DR OrthoDB; 5360131at2759; -.
DR TreeFam; TF352074; -.
DR Proteomes; UP000002280; Chromosome 2.
DR Bgee; ENSMODG00000028175; Expressed in spermatocyte and 6 other cell types or tissues.
DR GO; GO:0034751; C:aryl hydrocarbon receptor complex; IBA:GO_Central.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006805; P:xenobiotic metabolic process; IEA:InterPro.
DR CDD; cd19696; bHLH-PAS_AhR_like; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR039091; AHR/AHRR.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR10649; ARYL HYDROCARBON RECEPTOR; 1.
DR PANTHER; PTHR10649:SF17; ARYL HYDROCARBON RECEPTOR; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 25..78
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 121..184
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1055 AA; 117370 MW; 92FA4734D1275115 CRC64;
MVPAGGVYAV KKRKKPVPKS PKPPPPEGAK SNPSKRHRDR LNQELNRLTN LLPFPEDVQA
RLDKLSILRL TVGYLKVKSY FTAILKNPSA GQPEEQSANS GGDVKMPPDI NKDAFSEGDL
LLQALHGFLI AVTADGYIFY VSSTVQDHLG FHQSDIIYQS IFELIHTDDR TTFHHQLHWS
LKPTSFREAE QDSRSLPENE SPLNSGTTTC DPQHLPPENS SFLERSFVCR LRCLLDNSSG
FMALNFHGRL KFLHGQNKRA KDGSFMPPQL ALFALAVPLQ PLFLQELRTK IYFFQTKHKL
DFTPMACDAR GKVLLGYTET ELYRTGSGYQ LVHAADMMYC AEKHAKIMKI GESGMVIFRL
LTKKAGWLWV QSNARLMYKG GRPDCIVARQ RVLSNEEGEE HLHKRASSTF NFTTGEAILY
ENNLPGFLNS LHPRKEFRAK KEVNPNSHLG AMMHQDESVY ASQAISVPSF SLTDVIQAPR
EWGWGSNDKD EKLIKEDSDS LLTIIETLFE KSETGNDIYK SAPNLDADDL KLWRREEHMF
LMNQLGSPSF QGRLEQGVSS VRDEVIISPE NGKYMDFSPL NITMSLQSPR QQAPLMRTSC
KNTPNNALQY LLTNSTKEKD AGHSQEHYWH SLGPDAVVHL PPRFQEILPD FPQQTDGQSY
DSPLPFEKSP NSMSTPNIPG AFGQPSSMSA FSHGTSQYPL EPSLGNATTP FPPKSTSSLS
PEREGPEKKT QPSSLSDASA QSVQIRTHTH SNKWHDPEIV ENSGLSASQG LPQGAVPRCN
MDSATLGGPM EVKAQFRTKR AQADALGAHE TSPWISSKLA DYPKGDMKGM RMSPLSSPQQ
AQRTMMPCFG QQSTPLEGHQ LPGGHSSLWP TLQQGLLPVT GIYGGQQEFS TQHQQPLVQG
TELSPVPPRI ALGHPGVILM EAARHSTHHQ LAPDREAPQR ASASTSWHNE CSLSSPEYQS
NMPAMERNIS PQTSHTSPFL ASPNLSSSLG EAPSCCTDRL IASAPGRDKR LELDRRLLPH
PLDSPFSHKL LLEQQQDAQP IFSYDVPFKP SHQNE
//
