ID K7F2M2_PELSI Unreviewed; 438 AA.
AC K7F2M2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Small RNA binding exonuclease protection factor La {ECO:0000313|Ensembl:ENSPSIP00000002282.1};
GN Name=SSB {ECO:0000313|Ensembl:ENSPSIP00000002282.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000002282.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000002282.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGCU01052566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7F2M2; -.
DR STRING; 13735.ENSPSIP00000002282; -.
DR Ensembl; ENSPSIT00000002289.1; ENSPSIP00000002282.1; ENSPSIG00000002265.1.
DR eggNOG; KOG4213; Eukaryota.
DR GeneTree; ENSGT00830000128380; -.
DR HOGENOM; CLU_042341_0_0_1; -.
DR OMA; QFERSIY; -.
DR TreeFam; TF314476; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-UniRule.
DR GO; GO:0008266; F:poly(U) RNA binding; IEA:Ensembl.
DR GO; GO:1990825; F:sequence-specific mRNA binding; IEA:Ensembl.
DR GO; GO:0000049; F:tRNA binding; IEA:Ensembl.
DR GO; GO:0075522; P:IRES-dependent viral translational initiation; IEA:Ensembl.
DR GO; GO:0071045; P:nuclear histone mRNA catabolic process; IEA:Ensembl.
DR GO; GO:1903608; P:protein localization to cytoplasmic stress granule; IEA:Ensembl.
DR GO; GO:0042780; P:tRNA 3'-end processing; IEA:Ensembl.
DR GO; GO:0001682; P:tRNA 5'-leader removal; IEA:Ensembl.
DR GO; GO:0006409; P:tRNA export from nucleus; IEA:Ensembl.
DR CDD; cd08028; LARP_3; 1.
DR CDD; cd12291; RRM1_La; 1.
DR CDD; cd12541; RRM2_La; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045180; La_dom_prot.
DR InterPro; IPR006630; La_HTH.
DR InterPro; IPR014886; La_xRRM.
DR InterPro; IPR002344; Lupus_La.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22792:SF172; LUPUS LA PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR22792; LUPUS LA PROTEIN-RELATED; 1.
DR Pfam; PF05383; La; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF08777; RRM_3; 1.
DR PRINTS; PR00302; LUPUSLA.
DR SMART; SM00715; LA; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50961; HTH_LA; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS51939; XRRM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00332}.
FT DOMAIN 36..128
FT /note="HTH La-type RNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS50961"
FT DOMAIN 140..216
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 256..377
FT /note="XRRM"
FT /evidence="ECO:0000259|PROSITE:PS51939"
FT REGION 223..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 50117 MW; EEFDE4F41FACB4B4 CRC64;
MLKPNHPGLA WLLSEWEKVM SKVIPKIAKM AENGEGENMS ILENKICQQI EYYFGDHNLP
RDKFLKEQVK LDDGWVPLEI MIKFNRLSNL SKDFNVIIEA LRKSKSGLME ISEDKTKIRR
SPSKPLPEVN DQYKSAIKTR SVYIKGFPMD ATLDDIKEWL EGKGSVENIQ MRRTLNKTFK
GSIFAVFDSA ESAKTFREIP NQKYKDTELI VLLKEEYFTK KNEERKQNKA EAKAKAKQEK
EEKQKQAEDA EMKSLDEKTG CLLKFSGDLE DQTCREDLHA VFSDHGEIKW IDFVRGAKEG
IILFKDKAKE ALDKAEEANN GNLQLRNRDV IWELLEGDAE KEALKKIMEG QQESLNKWKA
KGHKFKGKGR GGKGTQGSQN KGKVQFQGKK IKFESEDEEG EENAKRGPAS PKKRPLEENE
KEEPASKQLK TENGAGDQ
//