ID K7FBY2_PELSI Unreviewed; 808 AA.
AC K7FBY2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Follistatin like 4 {ECO:0000313|Ensembl:ENSPSIP00000005542.1};
GN Name=FSTL4 {ECO:0000313|Ensembl:ENSPSIP00000005542.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005542.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000005542.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AGCU01039782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01039783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01039784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01039785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01039786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01039787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01039788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01039789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01039790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01039791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FBY2; -.
DR Ensembl; ENSPSIT00000005575.1; ENSPSIP00000005542.1; ENSPSIG00000005140.1.
DR eggNOG; ENOG502QPNV; Eukaryota.
DR GeneTree; ENSGT00940000158076; -.
DR HOGENOM; CLU_007849_0_0_1; -.
DR OMA; RYLPVCG; -.
DR TreeFam; TF350473; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR GO; GO:0048403; F:brain-derived neurotrophic factor binding; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0031549; P:negative regulation of brain-derived neurotrophic factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0048671; P:negative regulation of collateral sprouting; IEA:Ensembl.
DR GO; GO:0061000; P:negative regulation of dendritic spine development; IEA:Ensembl.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05736; IgI_2_Follistatin_like; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR10913; FOLLISTATIN-RELATED; 1.
DR PANTHER; PTHR10913:SF9; FOLLISTATIN-RELATED PROTEIN 4; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07648; Kazal_2; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF75011; 3-carboxy-cis,cis-mucoante lactonizing enzyme; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 58..112
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 150..185
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 225..298
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 316..401
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 808 AA; 91586 MW; 74E556D6C576325C CRC64;
MESDGTRRLS VDAGRLQQKE SRSFEVTRRK VLYGQDGLHA SCEKKYCGRG SKCVVNKETN
QPECKCLEDC KPSYMPVCGS DGKFYENHCE LHRASCLQRK KIYIIHSKDC FFKGDTCTMA
NYSRLKSILL DFQAHHHNQL GSPVEDRTFQ KRLLVEDLFK YLDINSDRHL SSAELAQLMK
KEALEDDFLD CTLEDLLRFD DYNNDGYLTL QELYTAFQVV QLTLPEEQKV SITTVTVGLS
AVLTCAIHGT LRPPIIWKRN GVILNFLDLE DINDFGEDDS LYITKVTTIH MGNYTCHAYG
YEELYQTHIL QVNVPPVIRV YPETQAQEPG VSASLKCHAE GIPNPRISWL KNGIDIMPKL
SKQLTLLANG SELHISSVRY EDTGAYTCIA KNEVGVDEDI SSLFIEDSAR KTRLSVGNMF
YVFSNDGVTI IQPNECEIRR HIKPSERIFT SYEEICPRAE GEAAQSCLWA SAVNVRDKYI
YVTQPKQNRL MIIDIQTQKV MQSIDVDPLP AKLHYDKSHD QVWVLSWGNM LKSHPTLQVI
TEASGGEIHH IIHTPFEDVD DFFIPPTNLI INHVRFGFVF NKSRSAVHKI DLETVTHIKT
ISFKNYSCKP QAMAYTHLGG YFFVQCKKNT STVASPQLII DSVTDSVIGP NSDISGTPYI
SPDGRYLVSA AEDSGRIKVQ AITIQGEIKL MYDLQTNVHI SDLTFQPSFT EGNQYYIYAT
SHLQTDVLFV ELSTGKMNVL KNLKDPIMSK DWPWNSDNRI MKDSGLFGQY LITPAKDSLF
VINGRQNTLH CEVSGIKRGN TMVWVGEV
//
