ID K7FBZ0_PELSI Unreviewed; 858 AA.
AC K7FBZ0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=PHD finger protein 14 {ECO:0000313|Ensembl:ENSPSIP00000005550.1};
GN Name=PHF14 {ECO:0000313|Ensembl:ENSPSIP00000005550.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005550.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000005550.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01029285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01029286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01029287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01029288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01029289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01029290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01029291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01029292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01029293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01029294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FBZ0; -.
DR STRING; 13735.ENSPSIP00000005550; -.
DR Ensembl; ENSPSIT00000005583.1; ENSPSIP00000005550.1; ENSPSIG00000005120.1.
DR eggNOG; KOG0957; Eukaryota.
DR GeneTree; ENSGT00940000156923; -.
DR HOGENOM; CLU_006506_0_0_1; -.
DR TreeFam; TF316118; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0002314; P:germinal center B cell differentiation; IEA:Ensembl.
DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR GO; GO:0060916; P:mesenchymal cell proliferation involved in lung development; IEA:Ensembl.
DR GO; GO:2000791; P:negative regulation of mesenchymal cell proliferation involved in lung development; IEA:Ensembl.
DR GO; GO:2000584; P:negative regulation of platelet-derived growth factor receptor-alpha signaling pathway; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd15674; ePHD_PHF14; 1.
DR CDD; cd15561; PHD1_PHF14; 1.
DR CDD; cd15562; PHD2_PHF14; 1.
DR CDD; cd15563; PHD3_PHF14; 1.
DR Gene3D; 2.30.30.1150; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF150; PHD FINGER PROTEIN 14; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 4.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 3.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 191..252
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 254..371
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 597..651
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 740..793
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 502..550
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..131
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..734
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..858
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 858 AA; 96942 MW; 20D3C4039B34935D CRC64;
MPTTEKDAIK TENKEQEEED EKPKKKKEKE KEKAIESDAA AAPAADEQAN EPKKWNLRRN
RPLLDFVSME ELNDMDDYDS EDDNDWRPTA GKKKGKTALR KEGSDGDNEE DEDDGSGSDE
EDNDEEGNED NSSTASDGGS KKKKNKVLSR TSADDEELTN DSLALSQSKS NEDSLILEKS
QNWTSQKMDH ILICCVCLGD NSEDADEIIQ CDNCGITVHE GCYGVDGESD SIMSSASENS
TEPWFCDACK CGVSPSCELC PNQDGIFKET DAGRWVHIVC ALYVPGVAFG DIDKLRPVTL
TEMNYSKYGA KECSFCEDPR FARTGVCISC DAGMCRAYFH VTCAQKEGLL SEAAAEEDIA
DPFFAYCKQH ADRLDRKWKR KNYLALQSYC KMSLQEREKQ LSPEAQARIN ARLQQYRAKA
ELARTTRPQA WVPREKLPRP LTSSASAIRK LMRKAELMGI STDIFPVDTS DTNSSVDGRR
KHKQPALTAD FVNYYLERNM RMIQIQENMA EQKNIKDKLE NEQEKLHVEY NKLCESLEEL
QNMNGKLRNE GQGIWTLLGR IIGQKLNIPT ILRAPKERKP SKKEGGTQKM STLPAVLYSC
GICKKNHDQH LLLLCDTCKL HYHLGCLDPP LTRMPRKTKN SYWQCSECDQ AGSSDMEADI
AMETLPDGTK RSRRQIKEPV KFVPQDVPPE PKKIPIRNTR TRGRKRSFVP EEEKPEERIP
RERRQRQSVL QKKPKSEDLR TECATCKGTG DNENLVRCDE CRLCYHFGCL DPPLKKSPKQ
TGYGWICQEC DSTSSKDSEP SIEVVSEAPG NVAPSSSRSS SEEQVAVAQK HPEEEDENEA
KEENSPQDLN MEEKNSKK
//
