ID K7FCV4_PELSI Unreviewed; 985 AA.
AC K7FCV4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 3 {ECO:0000313|Ensembl:ENSPSIP00000005864.1};
GN Name=SCUBE3 {ECO:0000313|Ensembl:ENSPSIP00000005864.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000005864.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000005864.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AGCU01037135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01037142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FCV4; -.
DR STRING; 13735.ENSPSIP00000005864; -.
DR Ensembl; ENSPSIT00000005899.1; ENSPSIP00000005864.1; ENSPSIG00000005357.1.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000153185; -.
DR OMA; TCALSCP; -.
DR TreeFam; TF351672; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0036122; F:BMP binding; IEA:Ensembl.
DR GO; GO:0070700; F:BMP receptor binding; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..985
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003905011"
FT DOMAIN 29..69
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 112..148
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 277..317
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 318..356
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 796..908
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 322..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 985 AA; 108691 MW; 6C4C1BCFA1C8D35F CRC64;
MGALQIAGFC SLFFLLHSGN TLANKASQDI DECVEGTDNC HIDALCQNTP KSYKCICKSG
YSGDGKHCKD VDECERDDNA GCVHECVNIP GNYRCTCYDG FRLAHDGHNC LDLDECSEGN
GGCQQTCVNM MGSYECHCRD GFFLSDNQHT CIQRPEEGMN CMNKNHGCAH ICRETPKGGI
ACECRPGFEL TKNQRDCKLT CNYGNGGCQH TCDDTDQGPK CGCHVKFVLH ADGKTCIETC
AVNNGGCDSK CHDAATGVHC SCPMGFMLQP DRKTCKDIDE CRLNNGGCDH ICRNTVGSFE
CSCKKGYKLL INERTCQDID ECSFDRTCDH ICVNTPGSFQ CLCHKGYTLY GLAHCGDIDE
CSINRGGCKF GCMNTAGSYE CTCPAGCKLH WNKKDCIELV KCLSGPMSHR AMLTCNRNGK
KDSCSLTCTS KARFLPESDS SYTVSCGTPV LRQGGPQRPG NSSHHCVETV AAPIKQKASF
KLKDAKCHLH PRVKGKPDES GKHGATGGAA PCSDCQVTFV NLKCDSSKKG KGRRARNSPN
KEVTRITLEF EAEIKPEEVT ASCNINCLRQ RVEKKLKAAI KALKKSINQE RFLIRFAGLE
YEVARKLSVA PERQESCGPG QQRLGSKCVS CLQGTYYHGQ MEQCVPCPPG TYQEKEGQLS
CDLCPGSDAY GPAGATNITT CAGQCPPGQY SVDGFIPCQP CPRGTYQPEA GRALCFPCGG
GLTTKHEGAF SFQDCDTKVQ CSPGHYYNTS VHRCIRCAVG TYQPDFRQNY CITCPGNTTT
DFDGSTSVSQ CKNRQCGGEL GEYTGYIESP NYPGNYPANI ECTWNINPPP KRKILIVVPE
IFLPSEDECG DVLVMRKNSS PSSITTYETC QTYERPIAFT ARSRKLWINF KTSEANSARG
FQIPYVTYDE DYEQLVEDIV RDGRLYASEN HQEILKDKKL MKAFFDVLAH PQNYFKYTEK
HKEMLPRSFI KLLRSKVSSF LRPYK
//
