ID K7FG42_PELSI Unreviewed; 899 AA.
AC K7FG42;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Gamma-tubulin complex component {ECO:0000256|RuleBase:RU363050};
GN Name=TUBGCP2 {ECO:0000313|Ensembl:ENSPSIP00000007002.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000007002.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000007002.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Gamma-tubulin complex is necessary for microtubule nucleation
CC at the centrosome. {ECO:0000256|RuleBase:RU363050}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337, ECO:0000256|RuleBase:RU363050}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGCU01108309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01108310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01108311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FG42; -.
DR STRING; 13735.ENSPSIP00000007002; -.
DR Ensembl; ENSPSIT00000007042.1; ENSPSIP00000007002.1; ENSPSIG00000006147.1.
DR eggNOG; KOG2001; Eukaryota.
DR GeneTree; ENSGT00940000156697; -.
DR OMA; QNMSGDP; -.
DR TreeFam; TF324047; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF13; GAMMA-TUBULIN COMPLEX COMPONENT 2; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363050};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU363050};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU363050};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 218..506
FT /note="Gamma tubulin complex component protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17681"
FT DOMAIN 509..869
FT /note="Gamma tubulin complex component C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04130"
SQ SEQUENCE 899 AA; 103360 MW; 785D84AE643A279A CRC64;
MSEFRIHHDV NELLSLLRVH GGEGAEVYID LLQKNRTPYV TTTVSAHSAK VKIAEFSRTP
EDFLKKYDEL KSKNTRNLDP LVYLLSKLTE DKETLQYLQQ NAKERAELAA NATTSGSSSF
TIPSTTSKIS MQELEELRKQ LGSVTTSSSV QQPLELIRKM LRDKQNKKNS GQPIPVFPAW
VYERSALNGD FLTGSSLSTD TTVPIGTLPL ASQESTVVED LLYVLIGVDG RYITAQPLIG
RQNRAFLVDP NLDMSVKELV TRILPVAASY STVTRFIEEK SSFEYGQVNH ALAAAMRTLI
KEYMILITQL EHLQRQGLLS LQKLWFYIQP TMRTMEILAS LATSVDKGEC MGGSTLSLLH
DRTFNYTGDS QAQELCLYLT KAASVPYFEI LEKWIYRGII NDPYSEFMVE EHELQKEKIQ
EDYNDKYWDQ RYTVVQQQIP SFLQKMADKI LSTGKYLNVV RECGCDVTCP EAKEIIYTLK
ERAYVEQIEK AYNYASRVLL DFLMEEKELV AHLSRSIKHY FLMDQGDFFV HFMDLTEEEL
KKPVDDIIPT RLEALLELAL RMSTANTDPF KDDLKIDLMP HDLITQLLRV LAIETKQEKA
IINADPTELT LSGLEAFSFD YIVKWPLSLI INRKALTRYQ MLFRHMFYCK HVERQLCNVW
ISNKAAKEYS LHSAKWFAGA FTLRQRMLNF VQNIQYYMMF EVMEPTWHVL EKNLKSASNI
DDVLSHHTSF LDNCLKDCML TNPELLKIFS KLMSVCVMFT NCMQRFTQSM KLNNEMGRLT
LEHGTMLGPP TEQERAEEAL KKQLTNKLLA EHADAFQLTS GFEATINKFD SNFSTHLLDL
LDKLSVYSTN DCEHSMINII YRLDFNGFYT ERLEHISAQR SQKVVSQAPL LPRVVVPTQ
//
