ID K7FK83_PELSI Unreviewed; 818 AA.
AC K7FK83;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Xylosyltransferase 1 {ECO:0000256|ARBA:ARBA00015604};
DE EC=2.4.2.26 {ECO:0000256|ARBA:ARBA00011972};
DE AltName: Full=Peptide O-xylosyltransferase 1 {ECO:0000256|ARBA:ARBA00030536};
DE AltName: Full=Xylosyltransferase I {ECO:0000256|ARBA:ARBA00032285};
GN Name=XYLT1 {ECO:0000313|Ensembl:ENSPSIP00000008443.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000008443.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000008443.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-
CC L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:50192, Rhea:RHEA-
CC COMP:9863, Rhea:RHEA-COMP:12567, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:57632, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132085; EC=2.4.2.26;
CC Evidence={ECO:0000256|ARBA:ARBA00001814};
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
CC -!- PATHWAY: Glycan metabolism; chondroitin sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004840}.
CC -!- PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005093}.
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 14 family. XylT
CC subfamily. {ECO:0000256|ARBA:ARBA00010195}.
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DR EMBL; AGCU01091358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01091359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01091360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01091361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01091362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01091363; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01091364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01091365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01091366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01091367; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006123701.1; XM_006123639.2.
DR AlphaFoldDB; K7FK83; -.
DR STRING; 13735.ENSPSIP00000008443; -.
DR Ensembl; ENSPSIT00000008487.1; ENSPSIP00000008443.1; ENSPSIG00000007632.1.
DR GeneID; 102461402; -.
DR KEGG; pss:102461402; -.
DR CTD; 64131; -.
DR eggNOG; KOG0799; Eukaryota.
DR GeneTree; ENSGT00940000157381; -.
DR HOGENOM; CLU_012840_0_0_1; -.
DR OMA; HWDFVIN; -.
DR OrthoDB; 4166917at2759; -.
DR TreeFam; TF315534; -.
DR UniPathway; UPA00755; -.
DR UniPathway; UPA00756; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030158; F:protein xylosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030206; P:chondroitin sulfate biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR003406; Glyco_trans_14.
DR InterPro; IPR043538; XYLT.
DR InterPro; IPR024448; XylT_C.
DR PANTHER; PTHR46025:SF2; XYLOSYLTRANSFERASE 1; 1.
DR PANTHER; PTHR46025; XYLOSYLTRANSFERASE OXT; 1.
DR Pfam; PF02485; Branch; 1.
DR Pfam; PF12529; Xylo_C; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 472..652
FT /note="Xylosyltransferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12529"
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 818 AA; 94320 MW; 0BD44A4E36DA29D4 CRC64;
MRTDSNNENS VPKDFENIDN SNFAPRTQRQ KYQPELMKKP LSKQKEHLKK KLEQEEKVKE
NSLLGKNSNE VLQFSHHAVK NSSSNLKESH RSPRQHHLKK SGNSSPEIRY DQPPKCEISG
KEAISALSRS KSKHCRREIA EVYCQHKQGK LMPEKVTRFC PLDGKANNNV QWDEDSVEYM
PANPVRIAFV LVVHGRASRQ LQRMFKAIYH KDHFYYIHVD KRSNYLHRKV LQFASQYPNV
RITPWRMATI WGGASLLSTY LQSMRDLIEM NDWPWDFFIN LSAADYPIRT NDQLVAFLSR
YRDMNFLKSH GRDNARFIRK QGLDRLFLEC DTHMWRLGDR KIPEGITLDG GSDWFLLNRK
FVEYVTFSSD DLVTKMKRFY SYTLLPAKSF FHTVLENSPH CDSMVDNNLR ITNWNRKLGC
KCQYKHIVDW CGCSPNDFKP ADFHRFQQTT RPTFFARKFE AVVNQEIIGQ LDYYLYGNYP
SGTPGLRSYW ENIYDEPDGI HSLSDVMLSM FHSFSRLGLR RAETSLHTDG DNSCRYYPMG
HPVSVQVYFL ADRFQGFLIK HHATNLAVSK LETLETWVMP KKMFKIASPP SDFGRLQFSE
IGTDWDAKER IFRNFGGLIG PMDEPVGMQK WGKGPNVTVT VIWVDPINVI AATYDILIES
SAEFTHYKPP LNLPLRPGVW TVKILHHWVP VAETKFLVTP LTFSNKQPIK QEESMKLHSG
PPKNAYMEQS FQGLNPVLNI PIKAAQVDQA KKNAALIGTK LENWVDTLVS NVWSAVDVCS
TGPTSCPVMQ ACTQTAWSSL SPDPKSELGP IKPDGRLR
//
