ID   K7FK94_PELSI            Unreviewed;       544 AA.
AC   K7FK94;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=THO complex 1 {ECO:0000313|Ensembl:ENSPSIP00000008454.1};
GN   Name=THOC1 {ECO:0000313|Ensembl:ENSPSIP00000008454.1};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC   Trionychidae; Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000008454.1, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000008454.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AGCU01201498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01201499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; K7FK94; -.
DR   STRING; 13735.ENSPSIP00000008454; -.
DR   Ensembl; ENSPSIT00000008498.1; ENSPSIP00000008454.1; ENSPSIG00000007691.1.
DR   eggNOG; KOG2491; Eukaryota.
DR   GeneTree; ENSGT00390000016232; -.
DR   HOGENOM; CLU_027906_0_0_1; -.
DR   OMA; DMLSACE; -.
DR   TreeFam; TF314796; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0000445; C:THO complex part of transcription export complex; IEA:Ensembl.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd08318; Death_NMPP84; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR021861; THO_THOC1.
DR   PANTHER; PTHR13265; THO COMPLEX SUBUNIT 1; 1.
DR   PANTHER; PTHR13265:SF2; THO COMPLEX SUBUNIT 1; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF11957; efThoc1; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT   DOMAIN          468..540
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
SQ   SEQUENCE   544 AA;  63325 MW;  F67B27BE58E15E17 CRC64;
     LNNIDTFALF QNTFYSAGKN YLLRMCNDLL RRLSKSQNTV FCGRIQLFLA RLFPLSEKSG
     LNLQSQFNLE NVTVFNTNEQ DSTLGQKHIE ERDEGMEVEE GEMGDDEAPT SCSIPIDYNL
     YRKFWSLQDY FRNPVQCYEK VSWKTFLKYS EEVLAVFKSY KLDDTQASRK KLEELKTGGE
     HVYFAKFLTS EKLMDLQLSD SNFRRHILLQ YLILFQYLKG QVKFKSSNYV LTDEQSLWIE
     DTTKLVYQLL SENPPDGERF SKMVEHILNT EENWNTWKNE GCPSFVKERP SDSKPTRLVR
     KRPAPEDFLG KGPNKKILMG NEELTRLWNL CPDNMEACKS ETREYMPTLE EFFEEAIEQA
     DPENMVENEY KAVNNSNYGW RALRLLARRS PHFFQPTNQQ FKSLPEYLEN MVIKLAKELP
     PPSEEIKTGE DEDEEDNDAL LKENNESPDV QRDKPVTGEQ IELFAIKLGE QWKILAPYLE
     MKDSDIRQIE SDSEDVKMRA KQLLVAWQDQ EGIHATPENL ITAMNKAGLS DLAESLMNDT
     ENSS
//