ID K7FMS3_PELSI Unreviewed; 565 AA.
AC K7FMS3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Rho guanine nucleotide exchange factor 3 {ECO:0000256|ARBA:ARBA00023847};
GN Name=ARHGEF3 {ECO:0000313|Ensembl:ENSPSIP00000009333.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009333.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009333.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RhoA
CC and RhoB GTPases. {ECO:0000256|ARBA:ARBA00043905}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AGCU01138697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01138698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01138699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01138700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01138701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01138702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01138703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01138704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01138705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01138706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006130973.1; XM_006130911.2.
DR RefSeq; XP_006130974.1; XM_006130912.2.
DR AlphaFoldDB; K7FMS3; -.
DR STRING; 13735.ENSPSIP00000009333; -.
DR Ensembl; ENSPSIT00000009379.1; ENSPSIP00000009333.1; ENSPSIG00000008446.1.
DR GeneID; 102458306; -.
DR KEGG; pss:102458306; -.
DR CTD; 50650; -.
DR eggNOG; KOG4305; Eukaryota.
DR GeneTree; ENSGT00940000158385; -.
DR OMA; QCVFREM; -.
DR OrthoDB; 24012at2759; -.
DR TreeFam; TF328974; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd10572; PH_RhoGEF3_XPLN; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR044129; PH_RhoGEF3_XPLN.
DR PANTHER; PTHR46006:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 163..345
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 375..490
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 44..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 65175 MW; ACDE3D4675E5ED47 CRC64;
MSATRPACIR SNPPIINQCP RGGMEEKKVW PKRQQPNNFS LFPSTKGWNF RGKKRKQSTQ
DEDAISICSL DAAEPSNKRV KPLSRVTSLA SLIPPVRATP LKRFSQTLQR SISFRSDSRP
DLFTPRQWSR NVPPASTKRR DSKLWSETFD VCVNQMLTSK EIKRQEAIFE LSQGEEDLIE
DLKLAKKAYH DPMLKLSIMT EQELNQIFGT LDSLIPLHED LLRRLQEVRK PDGSTEHVGH
ILVAWLPCLN SYDSYCSNQV AAKALLDHKK QDHRVQDFLQ RCLESPFSRK LDLWNFLDTP
RSRLVKYPLL LREILRHTPN DHPDQQHLEE AINIIQGIVA EINIKTGESE CQYYKERLIY
LEEGQKDSLI DNSRVVCCHG ELKNNRGAKL HVFLFQEVLV ITRTITHNEQ LCYQLYRQPI
PVKDLVLEDL QDGEVRLGGS IRGAFSNNER IKNFFRISFK SGSQSQSHSL QANDSFNKQQ
WLNCIRQAKE TVLCEGETGT LNSEEHCLIS PKGNRVQQRE NRLEQMDQSD NESDCSMDTS
EVNIDCERME QINSCENDKQ IETNI
//
