ID K7FNM1_PELSI Unreviewed; 343 AA.
AC K7FNM1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Renalase, FAD dependent amine oxidase {ECO:0000313|Ensembl:ENSPSIP00000009631.1};
GN Name=RNLS {ECO:0000313|Ensembl:ENSPSIP00000009631.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009631.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009631.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01074781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01074782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01074783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01074784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01074785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01074786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01074787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01074788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01074789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01074790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006121516.1; XM_006121454.2.
DR AlphaFoldDB; K7FNM1; -.
DR STRING; 13735.ENSPSIP00000009631; -.
DR Ensembl; ENSPSIT00000009678.1; ENSPSIP00000009631.1; ENSPSIG00000008739.1.
DR GeneID; 102457953; -.
DR CTD; 55328; -.
DR eggNOG; ENOG502QUZR; Eukaryota.
DR GeneTree; ENSGT00390000016052; -.
DR HOGENOM; CLU_036034_1_0_1; -.
DR OMA; ICGGDAF; -.
DR OrthoDB; 5394503at2759; -.
DR TreeFam; TF332799; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0051379; F:epinephrine binding; IEA:Ensembl.
DR GO; GO:0097621; F:monoamine oxidase activity; IEA:Ensembl.
DR GO; GO:0070404; F:NADH binding; IEA:Ensembl.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:Ensembl.
DR GO; GO:0045776; P:negative regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0010459; P:negative regulation of heart rate; IEA:Ensembl.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR040174; RNLS.
DR PANTHER; PTHR23357:SF1; RENALASE; 1.
DR PANTHER; PTHR23357; UNCHARACTERIZED; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..343
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003901956"
FT DOMAIN 98..332
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 343 AA; 38016 MW; A6AF589F7F1C2C84 CRC64;
MARVLIVGAG LTGSLCAALL RSELPQRPLS IALWDKARGA GGRMATSRSP HDPRCTADLG
AQYITLRPAY AQKHRSFYED LLTHGVLKPL TAPVEGMVME EGSHNFVTPQ GISSIVKHYL
TESDADVFYD YHVTQIYLRD GKWEVCKKTG SPEQFDIVVL TIPVPQILQL EGDIVNIIKE
SQKQQLESVS YSSRYALGLF YEAGTWIDVP WAAQYITNNP CIRFISIDNK KRNIESSEVG
PSVVVHTSVP FGIAHLEWNK EEVQAIILDH LENIMPGLPK PASIKCQKWR YSQVTKAIPN
SPGQMTLHIK PLLVCGGDGF THSNFDGCID SAICIVETLK TNL
//
