ID K7FNX1_PELSI Unreviewed; 337 AA.
AC K7FNX1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Microtubule-associated protein RP/EB family member 2 {ECO:0000256|ARBA:ARBA00019565};
GN Name=MAPRE2 {ECO:0000313|Ensembl:ENSPSIP00000009731.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009731.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009731.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the MAPRE family.
CC {ECO:0000256|ARBA:ARBA00010729}.
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DR EMBL; AGCU01034801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01034802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01034803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01034804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01034805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01034806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01034807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01034808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01034809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01034810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FNX1; -.
DR STRING; 13735.ENSPSIP00000009731; -.
DR Ensembl; ENSPSIT00000009778.1; ENSPSIP00000009731.1; ENSPSIG00000008817.1.
DR eggNOG; KOG3000; Eukaryota.
DR GeneTree; ENSGT00490000043329; -.
DR HOGENOM; CLU_041744_1_0_1; -.
DR OMA; WIKRFWD; -.
DR TreeFam; TF313620; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0032014; P:positive regulation of ARF protein signal transduction; IEA:Ensembl.
DR GO; GO:0120183; P:positive regulation of focal adhesion disassembly; IEA:Ensembl.
DR GO; GO:0051549; P:positive regulation of keratinocyte migration; IEA:Ensembl.
DR Gene3D; 1.20.5.1430; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR004953; EB1_C.
DR InterPro; IPR036133; EB1_C_sf.
DR InterPro; IPR027328; MAPRE.
DR PANTHER; PTHR10623; MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER; 1.
DR PANTHER; PTHR10623:SF7; MICROTUBULE-ASSOCIATED PROTEIN RP_EB FAMILY MEMBER 2; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF03271; EB1; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF140612; EB1 dimerisation domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51230; EB1_C; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Microtubule {ECO:0000256|PROSITE-ProRule:PRU00576};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 57..159
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 236..306
FT /note="EB1 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51230"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 337 AA; 38096 MW; 75FBB9FF0A33627D CRC64;
MPGPTQALSP NGENNNDILQ QDNGTIIPFR KHTVRGERSY SWGMAVNVYS TSITQETMSR
HDIIAWVNDI VALNYTKVEQ LCSGAAYCQF MDMLFPGCIS LKKVKFQAKL EHEYIHNFKL
LQASFKRMNV DKVIPVEKLV KGRFQDNLDF IQWFKKFFDA NYDGKEYDPV EARQGQDALP
PPDPGEQIFN LPKKSHHANS PTAGAAKSSP ASKPGSTPSR PSSAKKATPS SSASKSDKDL
ETQVIQLSEQ VHSLKLALEG VEKERDFYFG KLREIELLCQ EHGQENNDLV QRLMEVLYAS
EEHESHTDEH ESEEPVHEQP SRKNTDPSNI CDNFHCV
//
