ID K7FP06_PELSI Unreviewed; 879 AA.
AC K7FP06;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=P53-induced death domain protein 1 {ECO:0000313|Ensembl:ENSPSIP00000009766.1};
GN Name=PIDD1 {ECO:0000313|Ensembl:ENSPSIP00000009766.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009766.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009766.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01031696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01031697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01031698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7FP06; -.
DR STRING; 13735.ENSPSIP00000009766; -.
DR Ensembl; ENSPSIT00000009814.1; ENSPSIP00000009766.1; ENSPSIG00000008774.1.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000161780; -.
DR OMA; HRDNLGA; -.
DR TreeFam; TF331183; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1905369; C:endopeptidase complex; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0004175; F:endopeptidase activity; IEA:Ensembl.
DR GO; GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IEA:Ensembl.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR GO; GO:0043122; P:regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR019502; Peptidase_S68_pidd.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR45752; LEUCINE-RICH REPEAT-CONTAINING; 1.
DR PANTHER; PTHR45752:SF44; P53-INDUCED DEATH DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF10461; Peptidase_S68; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 5.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 318..451
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 452..593
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 795..863
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT ACT_SITE 441
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 443
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 583
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT ACT_SITE 585
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-1"
FT SITE 442..443
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
FT SITE 584..585
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR619502-2"
SQ SEQUENCE 879 AA; 98548 MW; A3AEAA7FCEE5F8AB CRC64;
APVDQQTMAE LLAVGEALGE GSLVTVAVKG CRLAGNRLNL DVYPDGCRQF LELFEKRRED
VVRVEFLRLN CNDALINSTL GSLPVLESLR SLVLKGGHAK DEFGACLQGS LTTLSEDFGS
LRCLAHLDLS FNSFSRLPSC ITDLTSLREL LVCHNSLVGL PEDFGRLTKL IFFSAMKNQL
RDLPRSIGEL AALQRLDLSE NTLQSLPDEI GRLGNCMELD LSGNQLMGIP DSLANLRSLQ
QLRLHSNLLV TVPASLASLP NLSRLDLQNN RLRSIPPEIQ SSPFVHLRGN PLGEPEIPLQ
SDESSSEELG RVILGPKEDR SFTVTPGGCK VILACGVRFY FPPGAATSSV TIHFQTLSPD
PRWVKLRHHD ILLSEVLELR PHGVEFQQEV QIWMPYTSPQ TLCKREVVVR TFDGQSWSDL
QTNVKRRGKP KKHMARCSVP HFSWFLVVSR LVENECSVPL EGTLLFSTVD PNIKVTFPPG
VTEETRSVRL QVLPVSAEEL EEITDDPESR ASPLLCLSQN STLDFLRPVK IQLPLPPGVT
GLTLDRSRLH LLHGDLQAQT WDDITNQVVL EFTHLYALFE VTHFSWYWLW YTTKAYIGGI
ARKVYKRLRM YQVNFIALQR KIDPEQVLLQ CVPKHKVDPV LGKLHDRYQG PEPSDIVEMF
EGEQFFAAFE RGISIDADRP DCVDGRISFI FYSHLKNMKE IYVTSEVDRK GQAVKGQVSF
YRGEVPDHVP EDATKKRKGP DSHWLATLPI KLPKLKSHGG EHADPKNGFS FPPLNLGNAE
TGYLTQANLL GIAGRIGLNL GLTYQQLQRI GCNHSQDLDG QILNMLFSWA QQNSEDQNCV
EKLITAMKES GRQDIADEIE TIIKLGRQKY RASIRRVGL
//
