ID K7FPM7_PELSI Unreviewed; 534 AA.
AC K7FPM7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=NADPH oxidase 3 {ECO:0000313|Ensembl:ENSPSIP00000009987.1};
GN Name=NOX3 {ECO:0000313|Ensembl:ENSPSIP00000009987.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000009987.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000009987.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AGCU01032457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01032458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01032459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01032460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01032461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01032462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01032463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01032464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014425010.1; XM_014569524.1.
DR STRING; 13735.ENSPSIP00000009987; -.
DR Ensembl; ENSPSIT00000010038.1; ENSPSIP00000009987.1; ENSPSIG00000009070.1.
DR GeneID; 102458501; -.
DR CTD; 50508; -.
DR eggNOG; KOG0039; Eukaryota.
DR GeneTree; ENSGT00940000160501; -.
DR HOGENOM; CLU_005646_3_1_1; -.
DR OrthoDB; 367877at2759; -.
DR TreeFam; TF105354; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0043020; C:NADPH oxidase complex; IEA:Ensembl.
DR GO; GO:0020037; F:heme binding; IEA:Ensembl.
DR GO; GO:0016175; F:superoxide-generating NAD(P)H oxidase activity; IEA:Ensembl.
DR GO; GO:0009590; P:detection of gravity; IEA:Ensembl.
DR GO; GO:0048840; P:otolith development; IEA:Ensembl.
DR GO; GO:0001659; P:temperature homeostasis; IEA:Ensembl.
DR CDD; cd06186; NOX_Duox_like_FAD_NADP; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR000778; Cyt_b245_heavy_chain.
DR InterPro; IPR013112; FAD-bd_8.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR InterPro; IPR013121; Fe_red_NAD-bd_6.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR11972; NADPH OXIDASE; 1.
DR PANTHER; PTHR11972:SF12; NADPH OXIDASE 3; 1.
DR Pfam; PF08022; FAD_binding_8; 1.
DR Pfam; PF01794; Ferric_reduct; 1.
DR Pfam; PF08030; NAD_binding_6; 1.
DR PRINTS; PR00466; GP91PHOX.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 250..357
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 534 AA; 61607 MW; 66D55822E55DAC34 CRC64;
MGCWIFNESL SVLLLMVWLG LNLYLFIDTF YWYEEDDAYL YTRVMLGCCR GVLRRQLDKN
LTFHKIVAYG IAANAIIHIV AHMVNIERYH ISQSKEAGGL RNKLSGIGKS PNESYLNPVR
SYEVSTTTQI LTTKAGVTGV VITLAFILIT TSSTEIIRRS FYEVFWYTHH LFLVFFIGLV
MHGMGQLIRG QTPQSLLLHN VTYCKEHYSE WEKVTHCPLP LFSGSEPVAW KWVLGPVVIY
ICERIVRFWR FQQEVVITKV VTHSSGVLEL HMKKCGFKME PGQYIFLQCP SVSQLEWHPF
TLTSAPEEEF FSVHIRVVGD WTGALFKAFG TEEKVFKEPW KLPRLAVDGP FGAPTTDVFH
YQVSVCIAAX XXXXXXXXXX XSILKSIWFK CCNPNTELTL EKVYFYWTCR DPSAFEWFAD
LLVLLETQMA EKGKPHFLSY HIFLTSWDES QATYIALHDD EKMDVITGLR QKTFYGRPNW
DSEFRQIAEN HPSNSIGVFF CGPKVLSKIL QKKCNLYSSA DPRSVQFHYN KESF
//
