UniProt: K7FXB1

Database: UniProt
Entry: K7FXB1_PELSI

LinkDB:  K7FXB1_PELSI 
Original site:  K7FXB1_PELSI

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Ontology (46)   
   GO (46)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (8)   
   EMBL (8)   
Protein domain (15)   
   InterPro (9)   
   Pfam (2)   
   PROSITE (2)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (76)   

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ID   K7FXB1_PELSI            Unreviewed;       739 AA.
AC   K7FXB1;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=Cullin 3 {ECO:0000313|Ensembl:ENSPSIP00000012671.1};
GN   Name=CUL3 {ECO:0000313|Ensembl:ENSPSIP00000012671.1};
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC   Trionychidae; Pelodiscus.
OX   NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000012671.1, ECO:0000313|Proteomes:UP000007267};
RN   [1] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG   Soft-shell Turtle Genome Consortium;
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000007267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
RN   [3] {ECO:0000313|Ensembl:ENSPSIP00000012671.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; AGCU01141619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01141620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01141621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01141622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01141623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01141624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01141625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGCU01141626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006131456.1; XM_006131394.1.
DR   STRING; 13735.ENSPSIP00000012671; -.
DR   Ensembl; ENSPSIT00000012732.1; ENSPSIP00000012671.1; ENSPSIG00000011411.1.
DR   GeneID; 102451845; -.
DR   KEGG; pss:102451845; -.
DR   CTD; 8452; -.
DR   eggNOG; KOG2166; Eukaryota.
DR   GeneTree; ENSGT00940000155066; -.
DR   HOGENOM; CLU_004747_7_1_1; -.
DR   OrthoDB; 21270at2759; -.
DR   TreeFam; TF105858; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005827; C:polar microtubule; IEA:Ensembl.
DR   GO; GO:0098794; C:postsynapse; IEA:GOC.
DR   GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR   GO; GO:0030332; F:cyclin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005112; F:Notch binding; IEA:Ensembl.
DR   GO; GO:0031208; F:POZ domain binding; IEA:Ensembl.
DR   GO; GO:0160072; F:ubiquitin ligase complex scaffold activity; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:Ensembl.
DR   GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR   GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR   GO; GO:0048208; P:COPII vesicle coating; IEA:Ensembl.
DR   GO; GO:0040016; P:embryonic cleavage; IEA:Ensembl.
DR   GO; GO:0044346; P:fibroblast apoptotic process; IEA:Ensembl.
DR   GO; GO:0007369; P:gastrulation; IEA:Ensembl.
DR   GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0072576; P:liver morphogenesis; IEA:Ensembl.
DR   GO; GO:0007080; P:mitotic metaphase chromosome alignment; IEA:Ensembl.
DR   GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0032480; P:negative regulation of type I interferon production; IEA:Ensembl.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:Ensembl.
DR   GO; GO:0032467; P:positive regulation of cytokinesis; IEA:Ensembl.
DR   GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IEA:Ensembl.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:Ensembl.
DR   GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR   GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
DR   GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR   GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
DR   GO; GO:0140252; P:regulation protein catabolic process at postsynapse; IEA:Ensembl.
DR   GO; GO:0017145; P:stem cell division; IEA:Ensembl.
DR   GO; GO:0043149; P:stress fiber assembly; IEA:Ensembl.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF168; CULLIN-3; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          361..606
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          649..669
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        653..669
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   739 AA;  85763 MW;  880D96844219CA31 CRC64;
     MTMDEKYVNS IWDLLKNAIQ EIQRKNNSGL SFEELYRNAY TMVLHKHGEK LYTGLREVVT
     EHLINKVRED VLNSLNNNFL QTLNQAWNDH QTAMVMIRDI LMYMDRVYVQ QNNVENVYNL
     GLIIFRDQVV RYGCIRDHLR QTLLDMIARE RKGEVVDRGA IRNACQMLMI LGLEGRSVYE
     EDFEAPFLEM SAEFFQMESQ KFLAENSASV YIKKVEARIN EEIERVMHCL DKSTEEPIVK
     VVERELISKH MKTIVEMENS GLVHMLKNGK TEDLACMYKL FSRVPNGLKT MCECMSSYLR
     EQGKALVSEE GEGKNPVDYI QGLLDLKSRF DRFLQESFNN DRLFKQTIAG DFEYFLNLNS
     RSPEYLSLFI DDKLKKGVKG LTEQEVETIL DKAMVLFRFM QEKDVFERYY KQHLARRLLT
     NKSVSDDSEK NMISKLKTEC GCQFTSKLEG MFRDMSISNT TMDEFRQHLQ ATGVSLGGVD
     LTVRVLTTGY WPTQSATPKC NIPPAPRHAF EVFRRFYLAK HSGRQLTXXX XXTFYGPVKK
     EDGSEVGVGG AQVTGSNTRK HILQVSTFQM TILMLFNNRE KYTFEEIQQE TDIPERELVR
     ALQSLACGKP TQRVLTKEPK SKEIENGHIF TVNDQFTSKL HRVKIQTVAA KQGESDPERK
     ETRQKVDDDR KHEIEAAIVR IMKSRKKMQH NVLVAEVTQQ LKARFLPSPV VIKKRIEGLI
     EREYLARTPE DRKVYTYVA
//

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