ID K7FXP1_PELSI Unreviewed; 738 AA.
AC K7FXP1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=ATP binding cassette subfamily D member 2 {ECO:0000313|Ensembl:ENSPSIP00000012801.1};
GN Name=ABCD2 {ECO:0000313|Ensembl:ENSPSIP00000012801.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000012801.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000012801.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCD family.
CC Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
CC {ECO:0000256|ARBA:ARBA00008575}.
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DR EMBL; AGCU01067531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067533; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01067537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006120468.1; XM_006120406.2.
DR AlphaFoldDB; K7FXP1; -.
DR STRING; 13735.ENSPSIP00000012801; -.
DR Ensembl; ENSPSIT00000012862.1; ENSPSIP00000012801.1; ENSPSIG00000011483.1.
DR GeneID; 102459778; -.
DR KEGG; pss:102459778; -.
DR CTD; 225; -.
DR eggNOG; KOG0064; Eukaryota.
DR GeneTree; ENSGT00950000182955; -.
DR HOGENOM; CLU_007587_1_1_1; -.
DR OMA; DIQAGHF; -.
DR OrthoDB; 7698at2759; -.
DR TreeFam; TF105205; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005777; C:peroxisome; IEA:Ensembl.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0047617; F:acyl-CoA hydrolase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:Ensembl.
DR GO; GO:0043217; P:myelin maintenance; IEA:Ensembl.
DR GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
DR GO; GO:1903427; P:negative regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
DR GO; GO:1990535; P:neuron projection maintenance; IEA:Ensembl.
DR GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IEA:Ensembl.
DR GO; GO:2001280; P:positive regulation of unsaturated fatty acid biosynthetic process; IEA:Ensembl.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR GO; GO:0042760; P:very long-chain fatty acid catabolic process; IEA:Ensembl.
DR CDD; cd03223; ABCD_peroxisomal_ALDP; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11384:SF24; ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 2; 1.
DR PANTHER; PTHR11384; ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER; 1.
DR Pfam; PF06472; ABC_membrane_2; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 111..347
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 479..705
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 738 AA; 83172 MW; 9142793B7807F59B CRC64;
MTQLLRAAAG RGKWTRSSAA RRAACLLAAA YGLKILYPVL RKRLQQTACE KGLQAACRAG
GGEEPLQCSR IRGRASPAVN AEFFRQLLEL RKILFPKLVS AESGWLCLHS VALVSRTFLS
IYVAGLDGKI VRSIVEKQPR SFAIKLIKWL MIAIPATFVN SAIRYLECKL ALAFRTRLVD
HAYETYFANQ TYYKVINMDG RLANPDQSLT EDLMMFSQSV AHLYSNLTKP ILDVVLTSYS
LIQTARSRGA SPIGPTLLAG LVVYATARVL KACSPKFGKL VAEEAHRKGY LRYVHSRIIA
NVEEIAFYRG HKVEMKQLQK SYKALADQMN LILSKRLWYI MIEQFLMKYV WSSCGLIMVA
VPIITATGFA DGELEDGQKQ AMVSERTEAF TTSRNLLVSG ADAIERIMSS YKEVTELAGY
TARVFNMFSV FDEVKRGIYK RTAVIQEIET YHKNEDKAEK HIDGPLEIKG KVIDVDHGII
CENVPIITPN GDVVVSRLNF KVQEGMHLLI TGPNGCGKSS LFRILSGLWP VYDGVLYKPP
PQHMFYIPQR PYMSIGTLRD QVIYPDSVDD MHEKGYQDQD LECILHVVHL YHIVQREGGW
DAVMDWKDVL SGGEKQRMGM ARMFYHKPKY ALLDECTSAV SIDVEGKIFQ AAKGSGISLL
SITHRPSLWK YHTHLLQFNG EGGWRFEQLD TAIRLSLSEE KQRLESQLAG IPEMQQRLNE
LCKILGEDSV LKTMAKED
//
