ID K7FZD6_PELSI Unreviewed; 1411 AA.
AC K7FZD6;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRU {ECO:0000313|Ensembl:ENSPSIP00000013396.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000013396.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000013396.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR EMBL; AGCU01012564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012568; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01012573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPSIT00000013459.1; ENSPSIP00000013396.1; ENSPSIG00000011351.1.
DR GeneTree; ENSGT00940000157151; -.
DR HOGENOM; CLU_001645_0_1_1; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14632; R-PTPc-U-1; 1.
DR CDD; cd14637; R-PTPc-U-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 721..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..164
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 166..257
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 264..359
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 362..460
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 461..567
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 873..1109
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1029..1100
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1141..1404
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1320..1395
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 799..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1411 AA; 159576 MW; B90B9C54DBE67045 CRC64;
AAGCTFEEDV DLNQCEYNQR EDDDFEWELI RSYAMPHLTS DLPHGSYLMV NSSQHAPGQK
AHLLFQTLSE NDTHCLQFSY FMYSRDGHSP GSLNVYVKVT GGPLGSMVWD MAGSHGRLWH
QAELAVSMFW PNEYQVLFEA VISGEHRGYL GLDDILLLNY PCSKAPHFSR LGDVEVNAGQ
NATFQCVAAG KALEAERFLL QRQNGAVAPA ASVKHISHRR FLATFQLDEV SKEEQDLYRC
VSQSVRGSGV SNFAELIVKE PPTPIAPPQL FRAGSTYLII QLNTNSIIGD GPIVRKEIEY
RMTSGPWSEV HAVSMQTYKL WHLDPDTEYE ISVLLTRPGD GGTGKPGPPL ISRTKCAEPM
RAPKGLAFSE IQSRQLTLQW EPLGYNLTRC HTYVVSLCYR YFVGTSHNQT FRECVKMEHS
THRYTIKNLL PYKNVHVKLI LSNPEGRKEG KEMIFQTDED VPGGIASESL TFTPLEDMIF
LKWEEPAEAN GLITQYEISY QSIESSDPAV NVPGPRRTVS KLRNETYHVF SNLHPGTTYL
FSVRARTGKG FGQTALTEIT TNISAPSFDY GDMPSPLSES ESTITVLLRP AQGRGAPIST
YQVIVEEDRP KKMRRELGGQ DCFPVPLTFD DAVARGSVHY FGGELPPSSL PEAKPFTVGD
NLTYGGYWNP PLEPKKAYLI YFQATSNLKG ETRLNCIRIA RKAACKESKR PLEVSQHSEE
MGLILGICAG GLVVLIILLG AIIVVIRKGK PVNMTKATIN YRHEKTHMMS AIDRSFTDQS
TLQEDERLGL SFMDAHNYSN RGDQRSSAVN ESSSLLGGSP RRQCGRKGSP YHTGQLHPAV
RVADLLQHIN QMKTAEGYGF KQEYESFFEG WDASKKKDKT KGRQDHMPTY DRHRVKLHPL
LGDPNSDYIN ANYIDGYHRS NHFIATQGPK QEMVYDFWRM VWQEHCSSIV MITKLVEVGR
VKCSKYWPDD TEMYGDIKIS LVKSEMLAEY AVRTFALERR GYSARHEVKQ FHFTSWPEHG
VPYHATGLLA FIRRVKATTP PDAGPIVIHC SAGTGRTGCY IVLDVMLDMA ECEGVVDIYN
CVKTLCSRRI NMIQTEEQYV FIHDAILEAC LCGETAIPVS EFKPTYKEMV RIEPQSNSSQ
LREEFQTLNS VTPHLDVEEC SIALLPRNRE KNRSMDVLPP DRCLPFLISM DGDSNNYINA
ALTDSYTKSA AFIVTLHPLQ NTTTDFWRLV YDYGCTSIVM LNQLNQSNSA WPCLQYWPEP
GLQQYGPIEV EYVSRSADED LVARLFRVQN ITRLQEGHLM VRHFQYLRWS AYRDTPDSKK
SFLHLLAQVE KWQEESGDGR TVVHCLNGGG RSGTFCASTM ILEMIKCHNM VDVFYAAKTL
RNYKPNMVEN LEQYHFCYDI ALEYLESLET R
//
