ID K7G3H2_PELSI Unreviewed; 1799 AA.
AC K7G3H2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000014833.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000014833.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR EMBL; AGCU01050539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01050540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01050541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01050542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01050543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01050544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 13735.ENSPSIP00000014833; -.
DR Ensembl; ENSPSIT00000014904.1; ENSPSIP00000014833.1; ENSPSIG00000013046.1.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000153617; -.
DR HOGENOM; CLU_001645_4_2_1; -.
DR OMA; XPGQPLN; -.
DR TreeFam; TF312900; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14628; R-PTP-D-2; 1.
DR CDD; cd14624; R-PTPc-D-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR045905; R-PTP-delta_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1152..1175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..107
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 119..201
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 208..298
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 303..399
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 401..490
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 495..592
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 597..705
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 706..803
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 804..899
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 904..990
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1242..1497
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1417..1488
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1529..1790
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1706..1781
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 284..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1799 AA; 201882 MW; CB2E10B133E81C1B CRC64;
EDQIPRGFPT IDMGPQLKVV ERTRTATMLC AASGNPDPEI TWFKDFLPVD TSNNNGRIKQ
LRSESIGGTP IRGALQIELS EESDQGKYEC VATNSAGTRY SAPANLYVRE LREVRRVPPR
FSIPPTNHEI MPGGSVNITC VAVGSPMPYV KWMLGAEDLT PEDDMPIGRN VLELNDVRQS
ANYTCVAMST LGVIEAIAQI TVKALPKPPG TPVVTESTAT SITLTWDSGN PEPVSYYIIQ
HKPKNSEELY KEIDGVATTR YSVAGLSPYS EYEFKVVAVN NIGRGPPSEP VSTRTSEQAP
SSAPRSVQAR MLSSTTILVQ WEEPEEPNGQ IQGYRVYYTM DPTQHVNNWM KHNVADSHIT
TIGNLVPQKT YSVKVLAFTS VGDGPLSTDI QVITQTGVPG QPLNFKAEPE SETSILLSWT
PPRSDTISSY ELVYKDGDQG EEQRVSVEPT TSYRLQSLKP NSLYYFRLAA RSPQGLGAST
AEISARTMQS KPSAPPQDIS CTSPSSTSIL VSWQPPPVEK QNGIITEYSI KYIGIDGEDD
KPHAILGIAS DTTQYLLENL EKWTEYRISV TAHTDVGPGP ESLSVLIRTD EDVPSGPPRK
VEVEAVNSTS VKVSWRSPVP NKQHGQIRGY QVHYVRMENG EPRGQPMLKD VMLADAQWEY
DDTAEHEMVI SGLQPETTYS LTVTAYTTKG DGARSKPKLV STTGAVPGKP RLVISHTQMN
TALIQWHPPV DTFGPLQGYR LKFGRKDLDM FTTLEFSEKE DHFTATDIHK GASYLFRLSA
RNKVGYGEEM VKEISVPEEV PSGFPQSLHS ESSTSTSVQL TWQPPVLAER NGIITKYTLL
YRNINVAHHP IELPIVPADT TMTLSGLKPD TTYDVKVRAH TSKGPGPYSP SVQFRTLPVD
QAVFAKNFHV KAVMKTSVLL SWEIPENYNS AMPFKILYDD GKMVVEVDGR ATQKLITNLK
PETSYSFVLT NRGNSAGGLQ HRVTAKTAPD VLRTKPVFIG KTNLDGMITV ELPEVPANEN
IKGYYIVIVP LKKSHGKFIK PWESPDEMEL DEHIVKELLR RGRSIRFGRE VELKPYIAAH
FEVLPTEFTL GDKKQYGGFE NKQLQSGQEY VFFVLAVMEH SESTMYATSP YSDPVVSMDL
DPQPITDEEE GLIWVVGPVL AVVFIICIVI AILLYKRKRA ESDSRKSSIP NSKEIPSHHP
TDPVELRRLN FQTPGMASHP PIPILELADH IERLKANDNL KFSQEYESID PGQQFTWEHS
NLEVNKPKNR YANVIAYDHS RVLLSAIEGI PGSDYVNANY IDGYRKQNAY IATQGALPET
FGDFWRMMWE QRGATVVMMT KLEERSRVKC DQYWPSRGTE TYGLIQVTLL DTVELATYCV
RTFALYKNGS SEKREVRQFQ FTAWPDHGVP EHPTPFLAFL RRVKTCNPPD AGPMVVHCSA
GVGRTGCFIV IDAMLERIKH EKTVDIYGHV TLMRAQRNYM VQTEDQYIFI HDALLEAVTC
GNTEVPARNL YAYIQKLTQI ETGENVTGME LEFKRLASSK AHTSRFISAN LPCNKFKNRL
VNIMPYESTR VCLQPIRGVE GSDYINASFI DGYRQQKAYI ATQGPLAETT EDFWRMLWEH
NSTIVVMLTK LREMGREKCH QYWPAERSAR YQYFVVDPMA EYNMPQYILR EFKVTDARDG
QSRTVRQFQF TDWPEQGVPK SGEGFIDFIG QVHKTKEQFG QDGPISVHCS NSAGVGRTGV
FITLSIVLER MRYEGVVDIF QTVKMLRTQR PAMVQTEDQY QFGYRAALEY LGSFDHYAT
//
