ID K7G8Y4_PELSI Unreviewed; 484 AA.
AC K7G8Y4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Glyoxylate reductase 1 homolog {ECO:0000313|Ensembl:ENSPSIP00000016745.1};
GN Name=GLYR1 {ECO:0000313|Ensembl:ENSPSIP00000016745.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000016745.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000016745.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily.
CC {ECO:0000256|ARBA:ARBA00007598}.
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DR EMBL; AGCU01096408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01096409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01096410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014429794.1; XM_014574308.1.
DR RefSeq; XP_014429795.1; XM_014574309.1.
DR AlphaFoldDB; K7G8Y4; -.
DR STRING; 13735.ENSPSIP00000016745; -.
DR Ensembl; ENSPSIT00000016821.1; ENSPSIP00000016745.1; ENSPSIG00000014926.1.
DR GeneID; 102456794; -.
DR KEGG; pss:102456794; -.
DR CTD; 84656; -.
DR eggNOG; KOG0409; Eukaryota.
DR eggNOG; KOG1904; Eukaryota.
DR GeneTree; ENSGT00940000156435; -.
DR HOGENOM; CLU_018075_0_0_1; -.
DR OMA; DIGNACK; -.
DR OrthoDB; 103196at2759; -.
DR TreeFam; TF324195; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000786; C:nucleosome; IEA:Ensembl.
DR GO; GO:0140463; F:chromatin-protein adaptor activity; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0031491; F:nucleosome binding; IEA:Ensembl.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:Ensembl.
DR GO; GO:0045815; P:transcription initiation-coupled chromatin remodeling; IEA:Ensembl.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 200..356
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 362..482
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT REGION 22..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 52332 MW; 9C0B93D3CCCB31A1 CRC64;
MIKINKGKRF QQAVDAVEEF LKKAKGKDQA SSHNSSEEKN RRNSSEERSK QSAGEEKRKA
GLSEGKLKKS TGEGKKRASS VSSERGSKSP LKRALDQSPR KRGRPPKDEK DLTIPESSTV
KRVMTGTVAG FKWPPGVSEP VKDGDPHFHH FLLSQTEKPA VCYQAITKKL KVCEEETGST
SIQAADSTAV NGSITPTDKK IGFLGLGLMG SGIVSNLLKM GHTVTVWNRT AEKCDLFIQE
GARLGRTPAE VVSTCDITFA CVSDPKAAKD LVLGPSGVLQ GIRPGKCYVD MSTVDADTVT
ELAQVIVSRG GRFLEAPVSG NQQLSNDGML VILAAGDRGL YEDCSSCFQA MGKTSFFLGE
VGNAAKMMLI VNMVQGSFMA TIAEGLTLAQ VTGQSQQTLL DILNQGQLAS IFLDQKCQNI
LQGNFKPDFY LKYIQKDLRL AIALGDSVNH PTPMAAAANE VYKRAKALDQ SDNDMSAVYR
AYIH
//
