ID K7G9P8_PELSI Unreviewed; 371 AA.
AC K7G9P8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=3 beta-hydroxysteroid dehydrogenase type 7-like {ECO:0000313|Ensembl:ENSPSIP00000017009.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000017009.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000017009.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; AGCU01026772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006114289.1; XM_006114227.2.
DR AlphaFoldDB; K7G9P8; -.
DR STRING; 13735.ENSPSIP00000017009; -.
DR Ensembl; ENSPSIT00000017087.1; ENSPSIP00000017009.1; ENSPSIG00000015150.1.
DR GeneID; 102456594; -.
DR KEGG; pss:102456594; -.
DR eggNOG; KOG1430; Eukaryota.
DR GeneTree; ENSGT00940000167381; -.
DR HOGENOM; CLU_007383_6_3_1; -.
DR OMA; PNTLCEP; -.
DR OrthoDB; 3675908at2759; -.
DR TreeFam; TF354279; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 8..272
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 371 AA; 42207 MW; 96132D9EED6E63CD CRC64;
MDKTLVYLVT GGCGFIGEHI VELLCKQDYI SEVRVFDSMA SEEVKKFATA STCVTVMKGD
IRDYALLLFA MRGVHLVIHT AGIVDIMDLV PFRDMEAVNV AGTENVLKAC CALSIPFLVY
TSSIAAVGPN TRREPMLRGT EDTKYTGEVE LPYGKTKAMA EKLVLEANGK ELSNGGKLAT
CIIRPNTVYG EKYQRLKDLY TTVKAKGGLL NYIVREDTER NLIYVGNVAW MHVLAARNLQ
LNPDVLAGQV YYSYDDTPAR KSYLVQYQLL TGIDPSIRLG SCIPYWKLRL LIYFYRIINI
LLYPFWKPRP FLNLPVLNTI ITTFFYETDK AFRHFGYTPL YSWEESKRRT IAWLKSATMN
LRAHQHHGKE M
//
