ID K7G9U3_PELSI Unreviewed; 1273 AA.
AC K7G9U3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=ERCC excision repair 6, chromatin remodeling factor {ECO:0000313|Ensembl:ENSPSIP00000017054.1};
GN Name=ERCC6 {ECO:0000313|Ensembl:ENSPSIP00000017054.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000017054.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000017054.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01052417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01052420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7G9U3; -.
DR STRING; 13735.ENSPSIP00000017054; -.
DR Ensembl; ENSPSIT00000017132.1; ENSPSIP00000017054.1; ENSPSIG00000015126.1.
DR eggNOG; KOG0387; Eukaryota.
DR GeneTree; ENSGT00940000158057; -.
DR HOGENOM; CLU_000315_7_2_1; -.
DR OMA; VKHDAIM; -.
DR TreeFam; TF101236; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0110016; C:B-WICH complex; IEA:Ensembl.
DR GO; GO:0090734; C:site of DNA damage; IEA:Ensembl.
DR GO; GO:0008023; C:transcription elongation factor complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0030296; F:protein tyrosine kinase activator activity; IEA:Ensembl.
DR GO; GO:0006284; P:base-excision repair; IEA:Ensembl.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:Ensembl.
DR GO; GO:0097680; P:double-strand break repair via classical nonhomologous end joining; IEA:Ensembl.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR GO; GO:0007254; P:JNK cascade; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:2001033; P:negative regulation of double-strand break repair via nonhomologous end joining; IEA:Ensembl.
DR GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IEA:Ensembl.
DR GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IEA:Ensembl.
DR GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0045945; P:positive regulation of transcription by RNA polymerase III; IEA:Ensembl.
DR GO; GO:0060261; P:positive regulation of transcription initiation by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006290; P:pyrimidine dimer repair; IEA:Ensembl.
DR GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
DR GO; GO:0000303; P:response to superoxide; IEA:Ensembl.
DR GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR GO; GO:0010224; P:response to UV-B; IEA:Ensembl.
DR GO; GO:0010165; P:response to X-ray; IEA:Ensembl.
DR GO; GO:0000012; P:single strand break repair; IEA:Ensembl.
DR GO; GO:0006362; P:transcription elongation by RNA polymerase I; IEA:Ensembl.
DR GO; GO:0006283; P:transcription-coupled nucleotide-excision repair; IEA:Ensembl.
DR CDD; cd22254; CSB_WHD; 1.
DR CDD; cd18000; DEXHc_ERCC6; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45629:SF7; DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED; 1.
DR PANTHER; PTHR45629; SNF2/RAD54 FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 290..466
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 615..774
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 128..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1114..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..170
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1273 AA; 145595 MW; B9BFA3BBDC90D4DD CRC64;
MLMPVQETEW EELIRTGQMT PFGTKVPQKI EKKPRRLMLN ETSDFEKYLA DQAKLSSERK
RSALKKRAKN RAELKKAQCA LPTLVKKEKR GKTRILSKTD KRLKKHMKKL QTHALQIQFK
IGIPKEKRLP ELQERLKGEQ GDESGESEYV PDEELFNPED EEEEPFSLAD DSSDYELKTL
PGARKHSGKR ILKEEAEEDE DFFPSSEEEE EESTIGNRRV KRCRDDGDED YYKQRLRRWH
KQRLKDKERR RMAEEDSDES DAEFDEGFRV PGFLFRKLFK YQQTGVRWLW ELHCQQAGGI
LGDEMGLGKT IQIIAFLAGL SYSKIRTRGS NYRFKGLGPT VIVCPATVMH QWVKEFHTWW
PPFRVAVLHE TGSYTNKKVK LIREIATCHG ILITSYSYIR LMQDHINNYD WHYVILDEGH
KIRNPNAAIT LACKQFRTPH RIILSGSPMQ NNLKELWSLF DFVFPGKLGT LPVFMEQFSV
PITMGGYSNA SPVQVKTAYK CACVLRDTIN PYLLRRMKAD VKMSLSLPDK NEQVLFCRLT
DEQRQVYQNF IDSKEVYQIL NGEMQIFSGL VALRKICNHP DLFSGGPKLL KGVPDDELEE
ADNFGYWKRS GKMIVVESLL KIWHKQGHRV LLFTQSRQML RILEVFLRDR NYSYLKMDGT
TTIASRQPLI MSYNQDTSIF VFLLTTRVGG IGVNLTGADR VIIYDPDWNP STDTQARERA
WRIGQKKQVT VYRLLTAGTI EEKIYHRQIF KQFLTNRVLK DPKQRRFFKS NDLYELFTLT
SPDGCQGTET SAIFAGTGSD VQAPKRQLKR KPEKPLDCAS KHDLHLKEHD SPKYDKPTDS
SSASHLMNSS KAIEPVGEIK GNLETFNQNS SVKDGTQATN NIDSLIEEEE KSMRPSEGSV
FQALPGNAQT SENVQCSNPT LTGEMHRAPS IPVGSRHSLI CEADSSQGKQ NGNLEDEQLV
NNPHKCTSKT KHGIAMQALE SHRGTSKKPK HHKGARFEGE RIPYLMKQKQ YRKGNQEEEE
EQKKNDDYVL EKLFKKSGIH SVMKHDVIME ASNPDYVLVE AEATRVAQDA LRALKISRQR
CLGAASGVPT WTGNSALTGA PSRLKSRFGQ KRNPTLLIPH SSTTSRGKKC KDADITRKEK
AKKNTPSVHF DGKIETESSS SALDSSSLLA KMRARNHLIL PQTMENESDE TLQASAPLPT
STEHDELLVD VRNFIAFQAR VDGEASTQEI LQEFESKLSM AQSCVFRELL RNLCTFHRSP
NGEGVWKLKP EFR
//
