ID K7GBA4_PELSI Unreviewed; 742 AA.
AC K7GBA4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=SH3 domain containing ring finger 2 {ECO:0000313|Ensembl:ENSPSIP00000017565.1};
GN Name=SH3RF2 {ECO:0000313|Ensembl:ENSPSIP00000017565.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000017565.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000017565.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SH3RF family.
CC {ECO:0000256|ARBA:ARBA00008649}.
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DR EMBL; AGCU01123083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01123084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01123085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01123086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01123087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7GBA4; -.
DR STRING; 13735.ENSPSIP00000017565; -.
DR Ensembl; ENSPSIT00000017644.1; ENSPSIP00000017565.1; ENSPSIG00000015585.1.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160067; -.
DR HOGENOM; CLU_015769_2_0_1; -.
DR OMA; KQYTSHP; -.
DR TreeFam; TF105571; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008157; F:protein phosphatase 1 binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR CDD; cd16749; RING-HC_SH3RF2; 1.
DR CDD; cd11932; SH3_SH3RF2_2; 1.
DR CDD; cd11784; SH3_SH3RF2_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR028511; SH3RF2_RING-HC_Zfn.
DR InterPro; IPR035794; SH3RF2_SH3_2.
DR InterPro; IPR035822; SH3RF2_SH3_3.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR14167:SF60; E3 UBIQUITIN-PROTEIN LIGASE SH3RF2; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00184; RING; 1.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 12..53
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 126..185
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 188..253
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 386..447
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 507..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..638
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 81333 MW; EB6485768F727234 CRC64;
MDDFALLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQGI LKSQNELRCP ECRTLVFCSI
EELPSNLLLI RLLDSVRYGQ NVTRFGSIQR SRVLTSPASI RRDRGDPRGL QLNQYRLAPN
PRIHTEGVPR ARALFSYRGQ NPGELRFNKG DIIVLLRQLD EKWYLGEMNG VSGVFPSSSV
QVIKQLPLPP PLCRALYNFD LRERDKNENK DCLTFHKGDI ITVISRVDEN WAEGKLGDKI
GIFPILFVEP NMTARQLLQT KKSHQSPPFK YSSPLRTASL KVKSTESPTF RKGSEPRRKS
LRPFSITTAL NTLNRMVHSP TGRQTLEISS PVLISSSNPT VATQSSEKLE FPYGTPVQVS
ASYYTAPGSL GHSTAIVTLP HLQQHISANM CVALHSYTAH GPEELDLQKG EGVRVLGKYQ
EGWFRGMSLV TGRVGIFPNN YVVPLFSCTS RKSSSFSESR MPSLYATWTL STASLSSQGS
ISESGPRQSR PLKSAFMPTA LSSPLRNLTV PAISGQTSLR RGRGSTRKNG SLQRPVQSGA
LTQVVGSLSR TPSLTVRPQQ LQLYQHVSCQ PHGTPAGGGT ADPGARSSAS HDASLLLVPR
GAESRPPSRC SSVILDAKEI PAKSEPAPKP PPSAPPSILV KPDTSRNSTE KQVKTVRFQN
YSPPPSKRHS SQPSPNHPGG KTEQGVAPEM TQLEANALGP DVLALYSHRI SSSPMHLRRT
LHPKTSSLDL SAQAGQLTFP TK
//
