ID K7GBW7_PELSI Unreviewed; 1168 AA.
AC K7GBW7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Ankyrin repeat and FYVE domain containing 1 {ECO:0000313|Ensembl:ENSPSIP00000017778.1};
GN Name=ANKFY1 {ECO:0000313|Ensembl:ENSPSIP00000017778.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000017778.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000017778.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01172332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01172333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01172334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7GBW7; -.
DR STRING; 13735.ENSPSIP00000017778; -.
DR Ensembl; ENSPSIT00000017859.1; ENSPSIP00000017778.1; ENSPSIG00000015710.1.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG4591; Eukaryota.
DR GeneTree; ENSGT00940000156179; -.
DR HOGENOM; CLU_010618_0_0_1; -.
DR OMA; WGLEQVV; -.
DR TreeFam; TF351263; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0044354; C:macropinosome; IEA:Ensembl.
DR GO; GO:0030904; C:retromer complex; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1901981; F:phosphatidylinositol phosphate binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0034058; P:endosomal vesicle fusion; IEA:Ensembl.
DR GO; GO:0090160; P:Golgi to lysosome transport; IEA:Ensembl.
DR GO; GO:0048549; P:positive regulation of pinocytosis; IEA:Ensembl.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR CDD; cd18501; BACK_ANKFY1_Rank5; 1.
DR CDD; cd18303; BTB_POZ_Rank-5; 1.
DR CDD; cd15728; FYVE_ANFY1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 6.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR049765; ANFY1_BTB_POZ.
DR InterPro; IPR049764; ANFY1_FYVE.
DR InterPro; IPR049763; ANKFY1_BACK.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR24118:SF99; CHARON; 1.
DR PANTHER; PTHR24118; POTE ANKYRIN DOMAIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01363; FYVE; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 21.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 10.
DR PROSITE; PS50088; ANK_REPEAT; 12.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 68..130
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REPEAT 288..320
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 490..522
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 541..567
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 620..652
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 653..685
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 768..800
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 801..824
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 869..901
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 904..936
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 937..969
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 970..991
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1042..1074
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1103..1163
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT COILED 6..40
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1168 AA; 129071 MW; 9B29286020F0DB6F CRC64;
CFAEDVAKLE KHLLLLRQEY VKLQKKLADT ERRCTLLAAK SNKENDSDSF ISRLLTIVAD
LYEQEQYSDL KIKVGDKRIN AHKFVLAARS ETWSLASLVS TEELDLSDAD PEVTMAMLRW
IYTDELELRE DDVFLTELMK LANRFQLQLL RERCEKGVMS LVNVRNCICF YQTAEELNAS
TLLNYCAEII ASHWDDLRKE DFSSMSAQLL YKMFKSKTEY PLHKAIKVER EDVVFLYLIE
MDSQLPGKLN ELDHNGDLAL DLALSRKLES IATTLVNYKA DVDMVDKRGW SLLHKAIQRG
DKFASNFLIK NGARVNAATL GDQETPLHLV ASYSPKKHFP DVMSEMAQIA ESLLQAGANP
NMQDCKGRTP LHASIVVRND PVFSQLLQCK QLDLELKDHE GSTALWLAVQ YITVSSDPSV
NPFDDVPVVN GTSFDENSFA ARLIQRGSNT DAPDTVTGNC LLQRAAGAGN EAAALFLATH
GAKVNHRNKW GETPLHTSCR HGLANLTAEL LQQGANPNIQ TEEAVPSRKD ATSPTASDNV
YLQTPLHMAI AYNHPDVVSV ILEQKANALH APNNLQIIPD FSLKDSRDQT VLGLALWTGM
HTIAAQLLGS GASINDTMSD GQTLLHMAIQ RQDSKSALFL LEHQADINVR TQDGETALQL
AIKNQLPLVV DAICTRGADM SVPDEKGNPP LWLALENHLE DIASTLVRHG CDATCWGPGP
SGCLQTLLHR AIDENSEPIA CFLIRSGCDV NSPRQPGANG EGEEEARDGQ TPLHLAACWG
LEEVIQCLLE FGANVNAQDA EGRTPIHVAI SNQHSVIIQL MISHPEIRLN MRDRQGMTPF
ACAMTYKNNK AAEAILKREP GAAEQVDNKG RNFLHIAVQN SDIESVLFLI SVQANVNSRV
QDASKLTPLH LAVQAGSEII VRNLLLAGAK VNELTKHRQT ALHLAAQQDL PTICSVLLEN
GVDFAAVDEN GNNALHLAVM HGRLNNIRIL LTECNVDAEA FNLRGQSPMH ILGHYGKDNA
AAICDLFLEC MPEYPLDKPD AEGNTVLLLA YMKGNANLCR AIVRAGARLG VNNNQGVNIF
NYQVATKQLL FRLLDMLSKE PPWCDGSNCY ECTAKFGVTT RKHHCRHCGR LLCHRCSTKE
IPIIKFDLNK PVRVCNICFD VLTLGGVS
//
