ID K7GDI4_PELSI Unreviewed; 2200 AA.
AC K7GDI4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Supervillin {ECO:0000313|Ensembl:ENSPSIP00000018345.1};
GN Name=SVIL {ECO:0000313|Ensembl:ENSPSIP00000018345.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000018345.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000018345.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
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DR EMBL; AGCU01003275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01003276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01003277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPSIT00000018431.1; ENSPSIP00000018345.1; ENSPSIG00000016175.1.
DR GeneTree; ENSGT00940000154653; -.
DR HOGENOM; CLU_001547_1_0_1; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR CDD; cd11280; gelsolin_like; 1.
DR CDD; cd11289; gelsolin_S2_like; 1.
DR CDD; cd11293; gelsolin_S4_like; 1.
DR CDD; cd11288; gelsolin_S5_like; 1.
DR Gene3D; 3.40.20.10; Severin; 5.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR007122; Villin/Gelsolin.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR PANTHER; PTHR11977:SF45; SUPERVILLIN; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF02209; VHP; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 4.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 5.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR PROSITE; PS51089; HP; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 2137..2200
FT /note="HP"
FT /evidence="ECO:0000259|PROSITE:PS51089"
FT REGION 34..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2200 AA; 248893 MW; 9EABF29D4F6E4FE2 CRC64;
MKRKERIARR LEGIENDTQP ILLQNCPGLV THRLLEEDTP RYMRATDSYS PHFGRSNEEE
ETSDSSIGKQ PRSSRYRAEP TGANSEPPYS TGAMDNQGLE SKAERIARYK AERRRQLAEK
YGLPLESEAD SEYLSRYTRP RKEPDTGDKK EVKSDKQEEE SKDFSSLYFS RSENKESLST
ASESKEHFFH EKDRVAEREE LSNLENKKAQ EVSAAGQAQD LSPEVDGSAS FSYSEQESSF
KEVPISPKQT CRLSLSSPKQ PVSPSHSHID QPFYSDTRQG TGKAKPEWFL QKDSEGDTPS
LISWPSRVKV REKLVKEESV HGSPELVTDT VSQKKSHPVP VDYMPLQSET SAFNRVANQT
FSSVRQQVYG CFQPAGVAHA AKLMATEDAK NISISSLLVP DNTGIMTKSP TATALEKEKS
NILQNYGSKP DEYPLGTEQL LKSRKPVLPP EVHRQGKSNE DHFTASEFDK SALSSAFISK
PKANSSELQK ALEFTKSQDP EPLFKTHEGT ERSETVLYIQ NGSVSHSAKA KGESQEVSMM
KHKLLTRSMS DYTGTPKSEA LKSKESVTKK EMAFQSSEAN VSNGEIGMVD TKVSVAQLRN
AFLETVSAHK KTELESQFEM STSGTDLSAN TERERGSRRP RRYFSPGESR KTSERFRTQP
ITSAERKETD RSSLSPELPA AEDEEKLDER AKLSVAAKRL LFREMEKSFE GKNIPKPHSR
NSAIERRLRR MQDRSRTQPV TTEEVVIAAT LQASVHQKTL AKEDIKEAKE AVEPDQSGEP
DSSTLSLAEK MALFNKLAQP VSKTISTRSR GDIRHRRMNA RYQTQPVTLG EVEQVQNGSE
KITPLSSAIL TSVSTMTSVI SPVYAGDLHA KSAADENVSA TSKVDLRCHS SLENADTPVK
GILKSEHWQP SVEAMESKRA SKEHEEEETN RFLAYEDNDV KKYSSFEETA THPVLSKTED
YHKEIKYTFP RKSSMELFTQ QALLQPLEQK EFVSDTVLQG KQEVKEGWSL EEKMEVENVL
KSKTLLRDHG EPTSELGMMS PQTDSQTVVS SRQREASEQL DEKFYRNPCE LFVAEDNKIE
TTEDYLDAPS KTLSIKERLA LLKKRGEESW RSRLNKKQEY GKMSVSERST QLQEAEQFFK
KKEEGRMTDD NDVSNQLWQK MADSHESQMT IEERKHLITV REEAWKTKGK GAANDSSQFT
VAGRMVKKGL ASPTAITPVT SPFCNRLKST TPVSKPLEEI EARPDLQLES DLKLDKLETF
LGRLNNKVGG MQETVLTVTG KSVKEVMKLD DDETFSKFYR HVDCPISTVP LELNEDFDAI
FDPYAPKLIS SVAEHKRAVR PMRRVQASRN PLKLLAARED ILHEYTEQRL NIAFMESKRM
KVEKMSANSN FSEVALAGLA SKENFSNVSL RSVNLTEQNS NNSAVPYKKL MLLQIKGRRH
VQTRLVEPRA SSLNSGDCFL LLTPHYCFLW VGEFANVIEK AKASELATLI QTKRELGCRA
SYVQTIEEGI NTHTHAAKDF WKLLGGQTSY QSAGSPEEDE MYEAAIIETN CIYRLVDDKL
IPDDDYWGKM PRCTLLQSKE VLVFDFGSEV YVWHGKEVTL AQRKVAFQLA KHLWNGTFDY
ANCDINPLDP GECNPLIPRK GQGRPDWAIF GRLTEHNETI LFKEKFLDWT ELKKHNEKNS
SESLHQKEDP RSDFKPYDVM LMVPVPQTTV GTVLDGINIG RGYGFVEGED GRQFEIITAS
VDVWHILEFD YSRLPKQSIG QFHEGDTYVV KWKYMVSTAV GSRQKGEQQV RAVGKEKCVY
YFWQGRHSTV SEKGTSALMT VELDEERGAQ VQVLQGKEPP CFLQCFQGGM IVHAGRREEE
EENTQSDWRL YCVRGEVAIE GNLLEVACHC SSLRSRTSMI VLNINKALIY LWHGCKAQSH
TKDVGRTAAN KIKEQCPLEA GLHSSSKVTI HECDEGSEPL GFWDALGRRD RKAYDCMLQD
PGKFNFTPRL FILSSSSGDF SATEYIYPAR DPAVVNSMPF LQEDLYTAPQ PALFLVDNHH
EVYLWQGWWP VENKITGSAR IRWATDRKCA METVLQYCKG KNVKKPPKSY LIHAGLEPLT
FTNMFPSWEH REDIAEITEM DAEVSNQIIL VEDVLAKLCK TVYPLADLLA RPLPEGVDPL
KLEIYLSDED FEVALEMTRE EYNALPSWKQ VNVKKAKGLF
//
