ID K7GG62_PELSI Unreviewed; 439 AA.
AC K7GG62;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Serine/threonine-protein kinase ULK3 {ECO:0000256|ARBA:ARBA00021644};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE AltName: Full=Unc-51-like kinase 3 {ECO:0000256|ARBA:ARBA00032242};
GN Name=ULK3 {ECO:0000313|Ensembl:ENSPSIP00000019273.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000019273.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000019273.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AGCU01107727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01107728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01107729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01107730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7GG62; -.
DR STRING; 13735.ENSPSIP00000019273; -.
DR Ensembl; ENSPSIT00000019363.1; ENSPSIP00000019273.1; ENSPSIG00000017047.1.
DR eggNOG; KOG0595; Eukaryota.
DR GeneTree; ENSGT00940000157689; -.
DR HOGENOM; CLU_000288_63_58_1; -.
DR OMA; CIERSIL; -.
DR TreeFam; TF324551; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:Ensembl.
DR GO; GO:0072537; P:fibroblast activation; IEA:Ensembl.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR CDD; cd02684; MIT_2; 1.
DR CDD; cd14121; STKc_ULK3; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR045269; Atg1-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24348; SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED; 1.
DR PANTHER; PTHR24348:SF65; SERINE_THREONINE-PROTEIN KINASE ULK3; 1.
DR Pfam; PF04212; MIT; 2.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00745; MIT; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF116846; MIT domain; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 1..264
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 439 AA; 50454 MW; 37813F3A5ED83936 CRC64;
MGVLGISRSR GKLLDVDSPP AWFPFPFQKN TREVVAIKCV NKKSLNRASV ENLLTEIEIL
KTIRHPHVVE LKDFQWDSDN IYLIMEFCAG GDLSRFIRMR KILPEKVARL FLQQLAWALK
FLHDRKISHL DLKPQNILLS SLENPHLKLA DFGFAQYMSP WDEKHVLRGS PLYMAPEMVC
SRQYDARVDL WSTGVILYEA LFGRPPFFSK SFAELEEKIR SNRVIELPSR PRLSQECRDL
LQRLLERDPQ QRISFEEFFA HPFVDMEHMP SSESLSKATA LVVEAVKKDQ QADPAAALSL
YCKALEYFVP ALHYETDARR KEAIRSKVGQ YISRAEELKA LVTSNNKTLL QQGSPTRNIL
REMARDKPRL YAALEVASAA IAKEEEGKDD SDTLDLYQQS LGELLLMLAA EPVGRRRELL
HAEIQTLMGR AEYLKEQIK
//
