ID K7GK29_PELSI Unreviewed; 701 AA.
AC K7GK29;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Pre-rRNA-processing protein TSR1 homolog {ECO:0000256|ARBA:ARBA00040070};
GN Name=TSR1 {ECO:0000313|Ensembl:ENSPSIP00000020640.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000020640.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000020640.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required during maturation of the 40S ribosomal subunit in
CC the nucleolus. {ECO:0000256|ARBA:ARBA00037087}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Bms1-like GTPase family. TSR1 subfamily.
CC {ECO:0000256|ARBA:ARBA00038288}.
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DR EMBL; AGCU01051747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01051748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7GK29; -.
DR STRING; 13735.ENSPSIP00000020640; -.
DR Ensembl; ENSPSIT00000020737.1; ENSPSIP00000020640.1; ENSPSIG00000018258.1.
DR eggNOG; KOG1980; Eukaryota.
DR GeneTree; ENSGT00940000153195; -.
DR HOGENOM; CLU_009858_1_0_1; -.
DR OMA; MNLPRFK; -.
DR TreeFam; TF105717; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR012948; AARP2CN.
DR InterPro; IPR039761; Bms1/Tsr1.
DR InterPro; IPR007034; BMS1_TSR1_C.
DR InterPro; IPR030387; G_Bms1/Tsr1_dom.
DR PANTHER; PTHR12858:SF1; PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG; 1.
DR PANTHER; PTHR12858; RIBOSOME BIOGENESIS PROTEIN; 1.
DR Pfam; PF08142; AARP2CN; 1.
DR Pfam; PF04950; RIBIOP_C; 1.
DR SMART; SM00785; AARP2CN; 1.
DR SMART; SM01362; DUF663; 1.
DR PROSITE; PS51714; G_BMS1; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT DOMAIN 1..141
FT /note="Bms1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51714"
FT REGION 301..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..323
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 701 AA; 80676 MW; D1F4BE27F2F75B71 CRC64;
LRALQSDGAA VVHRDERAEG FVLLSPQFKQ RWRFVTAHMG NLHAVLDLAK VADTLLFVLD
PLDGWDSTGD YYLSCLFAQG LPSYALAVLG VPDLPQKKQA DAKKKLGKAI EKRFPDAKLF
PLNTEQESLL LLRHLAAQKQ RHLAFRDRRA YLLAHNAEFV PSRDSDLVGN LKVSGYVRGW
TLNVNSLVHI VGHGDFQMSQ VDAPPDPFTL NPRVAKGQQK KGQDMEIQVS ICPHSQQSAS
VLMQPRKQQP LQSEVIPDPM EGEQTWPTEE ELKDAEGSLK KRRKVLKVPK GTSNYQAAWI
VDDGEDGSEE EEEDDNMEDE DLMEEASQVV ESSEEEELAE EECETMTIAE SARDDLYDEK
VDEDEEQMLE KYRQERLDQM FPDEVDTPRN LPARVRFQKY RGLKSFRTSP WDPKENLPRD
YARIFQFQDF SRTRKHVFRQ LEKEETEGAM VGWYVTLHIC SVPISVMESF RQGMPMVLFS
LLPHEQKMSV LNFVVRRHLG NSDTVKAKEE LIFHCGFRRF RASPLYSQHS SADKHKLEHF
LRPDAALVAT VYAPIAFPPA SVLLFKQRSN GMHDLIATGS LLSVDPDRII IKRLVLSGHP
FKIFSKTAVV RYMFFNREDV LWFKPVELRT KWGRRGHITE PLGTHGHMKC HFDGQLKSQD
TVLLNLYKRV FPKWTYDPHV PEPVPWARNE QQLFMQELEM E
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