ID K7GLQ2_PIG Unreviewed; 1061 AA.
AC K7GLQ2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 {ECO:0000313|Ensembl:ENSSSCP00000028784.3};
GN Name=SMARCA1 {ECO:0000313|Ensembl:ENSSSCP00000028784.3,
GN ECO:0000313|VGNC:VGNC:93225};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000028784.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000028784.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000028784.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000028784.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC {ECO:0000256|ARBA:ARBA00009687}.
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DR RefSeq; XP_003360492.1; XM_003360444.3.
DR AlphaFoldDB; K7GLQ2; -.
DR SMR; K7GLQ2; -.
DR STRING; 9823.ENSSSCP00000028784; -.
DR PaxDb; 9823-ENSSSCP00000013448; -.
DR Ensembl; ENSSSCT00000033549.3; ENSSSCP00000028784.3; ENSSSCG00000012649.6.
DR GeneID; 100188905; -.
DR CTD; 6594; -.
DR VGNC; VGNC:93225; SMARCA1.
DR GeneTree; ENSGT00940000157297; -.
DR InParanoid; K7GLQ2; -.
DR OrthoDB; 5482994at2759; -.
DR Proteomes; UP000008227; Chromosome X.
DR Bgee; ENSSSCG00000012649; Expressed in Ammon's horn and 41 other cell types or tissues.
DR ExpressionAtlas; K7GLQ2; baseline and differential.
DR Genevisible; K7GLQ2; SS.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IBA:GO_Central.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:2000177; P:regulation of neural precursor cell proliferation; IEA:Ensembl.
DR CDD; cd18065; DEXHc_SMARCA1; 1.
DR CDD; cd00167; SANT; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR015194; ISWI_HAND-dom.
DR InterPro; IPR036306; ISWI_HAND-dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR015195; SLIDE.
DR InterPro; IPR044755; SMARCA1_N.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF49; SWI_SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 1; 1.
DR Pfam; PF09110; HAND; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09111; SLIDE; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 198..363
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 493..644
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 846..898
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 28..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..840
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1061
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 123120 MW; 26DBAA3ED3FBC538 CRC64;
MEPDTAAVAA TVAASDATAT IVVIEDEQPG PSISKEEGAA AAATASTEAT VATEKGEKKK
EKNASPFQLK LAAKASKSEK EMDPEYEEKM KADRAKRFEF LLKQTELFAH FIQPSAQKSP
TSPLNIKLGR PRIKKDDKQS LISAGDYRHR RTEQEEDEEL LSESRKTSNV CVRFEVSPSY
VKGGPLRDYQ IRGLNWLISL YENGVNGILA DEMGLGKTLQ TIALLGYLKH YRNIPGPHMV
LVPKSTLHNW MNEFKRWVPS LRVICFVGDK DARAAFIRDE MMPGEWDVCV TSYEMVIKEK
SVFKKFHWRY LVIDEAHRIK NEKSKLSEIV REFKSTNRLL LTGTPLQNNL HELWALLNFL
LPDVFNSADD FDSWFDTKNC LGDQKLVERL HAVLKPFLLR RIKTDVEKSL PPKKEIKIYL
GLSKMQREWY TKILMKDIDV LNSAGKMDKM RLLNILMQLR KCCNHPYLFD GAEPGPPYTT
DEHIVSNSGK MVVLDKLLAK LKEQGSRVLI FSQMTRLLDI LEDYCMWRGY EYCRLDGQTP
HEEREEAIEA FNVPNSSRFI FMLSTRAGGL GINLASADVV ILYDSDWNPQ VDLQAMDRAH
RIGQKKPVRV FRLITDNTVE ERIVERAEIK LRLDSIVIQQ GRLIDQQSNK MAKEEMLQMI
RHGATHVFAS KESELTDEDI TTLLERGERK TAEMNERLQK MGESSLRNFR MDTEQSLYKF
EGEDYREKQK LGMVEWIEPP KRERKANYAV DAYFREALRV SEPKVPKAPR PPKQPNVQDF
QFFPPRLFEL LEKEILYYRK TIGYKVPRNP DIPNPAVAQR EEQKKIDGAE PLTPEETEEK
EKLLTQGFTN WTKRDFNQFI KANEKYGRDD IDNIAREVEG KSPEEVMEYS AVFWERCNEL
QDIEKIMAQI ERGEARIQRR ISIKKALDAK IARYKAPFHQ LRIQYGTSKG KNYTEEEDRF
LICMLHKMGF DRENVYEELR QCVRNAPQFR FDWFIKSRTA MEFQRRCNTL ISLIEKENME
IEERERAEKK KRATKTPMSQ KRKAESATES SGKKDVKKVK S
//
