ID K7GNH0_PIG Unreviewed; 543 AA.
AC K7GNH0; A0A5K1U639; K7GKJ1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Acyloxyacyl hydrolase {ECO:0000313|Ensembl:ENSSSCP00000029423.4};
GN Name=AOAH {ECO:0000313|Ensembl:ENSSSCP00000029423.4,
GN ECO:0000313|VGNC:VGNC:85374};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000029423.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000029423.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000029423.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000029423.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; K7GNH0; -.
DR STRING; 9823.ENSSSCP00000029423; -.
DR PaxDb; 9823-ENSSSCP00000029423; -.
DR Ensembl; ENSSSCT00000034056.4; ENSSSCP00000029423.4; ENSSSCG00000016657.6.
DR VGNC; VGNC:85374; AOAH.
DR GeneTree; ENSGT00390000008427; -.
DR InParanoid; K7GNH0; -.
DR OrthoDB; 4166at2759; -.
DR TreeFam; TF329246; -.
DR Proteomes; UP000008227; Chromosome 18.
DR Bgee; ENSSSCG00000016657; Expressed in blood and 33 other cell types or tissues.
DR ExpressionAtlas; K7GNH0; differential.
DR Genevisible; K7GNH0; SS.
DR GO; GO:0050528; F:acyloxyacyl hydrolase activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0009104; P:lipopolysaccharide catabolic process; IBA:GO_Central.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IBA:GO_Central.
DR CDD; cd01826; acyloxyacyl_hydrolase_like; 1.
DR Gene3D; 1.10.225.10; Saposin-like; 1.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR039676; AOAH.
DR InterPro; IPR048593; AOAH_Saposin_N.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR011001; Saposin-like.
DR InterPro; IPR008139; SaposinB_dom.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR15010; ACYLOXYACYL HYDROLASE; 1.
DR PANTHER; PTHR15010:SF0; ACYLOXYACYL HYDROLASE; 1.
DR Pfam; PF00657; Lipase_GDSL; 1.
DR Pfam; PF20825; Saposin; 1.
DR SUPFAM; SSF47862; Saposin; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR PROSITE; PS50015; SAP_B; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:K7GNH0};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..543
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036493556"
FT DOMAIN 46..86
FT /note="Saposin B-type"
FT /evidence="ECO:0000259|PROSITE:PS50015"
SQ SEQUENCE 543 AA; 61967 MW; 3A20FA7B58532016 CRC64;
MKSPRKVLMV APLIFLLTVH TSASPAYDDQ PSTRHSDGHV CIEKLFLKTT CYVVVRMFGP
DIIKLLEAKL NADVVCHTLK FCKQDPGQPL CHLYPLPKEA WKFTLTKARQ IVKKSPTLTY
SRSDSDICSL PFLAKICQKI KLAIENSLPF KDTDSDKYSV FPTLRGYHWR GRDCNDNDKM
VYPGRRPNSW DVHQDSNCNG IWGVDPKDGI PYEKKFCEGS QPRGIILLGD SAGAHFHIPP
EWITASQMSL KSFFNLPAAL TDELNWPQLS GATGFLNSTS GLKENSIYLR LRKRNRCNHR
DYQNISRNGA SSQNLESFIE SLSRNQLLDH PAIVIYAMIG NDVCNGKTNP VPAMTTPEKL
FSKVMQTLQY LDSHLPNGSH VILFGLPDGT FLWDNLHNRY HPLGQLNKDV TYEHFYSFLN
CLQVSPCHGW MSSNRTLRTL TSERAEQLSS TLKRIATSQK FANFNLFYMD FDFREIMEEW
RKRGGQPWQL IEPVDGFHPN EVALQLLADG FWKKAQLQWP QVLGKENPFN HQIEQVFGDQ
GGH
//
