ID K7RZN2_BOTSH Unreviewed; 531 AA.
AC K7RZN2;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Histocompatibility ligand membrane bound form {ECO:0000313|EMBL:AFV95056.1};
DE SubName: Full=Membrane-bound cFuHC {ECO:0000313|EMBL:AGS14998.1};
GN Name=fuhc {ECO:0000313|EMBL:AFV95056.1};
OS Botryllus schlosseri (Golden star tunicate) (Alcyonium schlosseri).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC Styelidae; Botryllus.
OX NCBI_TaxID=30301 {ECO:0000313|EMBL:AFV95056.1};
RN [1] {ECO:0000313|EMBL:AFV95056.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AA1023 {ECO:0000313|EMBL:AFV95056.1};
RX PubMed=23826085;
RA Nydam M.L., Netuschil N., Sanders E., Langenbacher A., Lewis D.D.,
RA Taketa D.A., Marimuthu A., Gracey A.Y., De Tomaso A.W.;
RT "The Candidate Histocompatibility Locus of a Basal Chordate Encodes Two
RT Highly Polymorphic Proteins.";
RL PLoS ONE 8:E65980-E65980(2013).
RN [2] {ECO:0000313|EMBL:AGS14998.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23888037; DOI=10.1126/science.1238036;
RA Voskoboynik A., Newman A.M., Corey D.M., Sahoo D., Pushkarev D., Neff N.F.,
RA Passarelli B., Koh W., Ishizuka K.J., Palmeri K.J., Dimov I.K., Keasar C.,
RA Fan H.C., Mantalas G.L., Sinha R., Penland L., Quake S.R., Weissman I.L.;
RT "Identification of a colonial chordate histocompatibility gene.";
RL Science 341:384-387(2013).
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DR EMBL; JX625138; AFV95056.1; -; mRNA.
DR EMBL; KF017889; AGS14998.1; -; mRNA.
DR AlphaFoldDB; K7RZN2; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR23277:SF108; HEMICENTIN-1; 1.
DR PANTHER; PTHR23277; NECTIN-RELATED; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..531
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010970887"
FT TRANSMEM 377..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..121
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 136..232
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 409..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..514
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 59264 MW; B5B5D2B971DE3EEC CRC64;
MKKAFILQVI LGVLRLSDSV DLKYDDVSYA TVHQSAFLRC GMMPVQPIKE LWWFKIGASE
ERVYYYDPTS VDAALMKRAR RSNRDNTSLE IYPTQLSDEG EYKCRIVVWD NTGNSTEPSV
PISKEARMML KVNVPPEKVE ITHLTSGRNL SLRCKSEGAK PPADILWTKT SPDGVETEIP
DLAKTREIEP AGELYDTAEQ IFYQLEENEM IAKISCVVRH HNTNTTIYKN ITFVSPAIQN
ALKVTIQRFA EPVLYSSIEN QDGQDNKAGL VKISADPGFK VPYNTSVTLK AAAPGVFPEP
RYLWWVGDQT GIAGRELRID NLEEDKSYYV LAENPLGRVV LEVPVHITIS DYSQWNDSSR
DGDVNEGDTT EGLDTGAIIG IVIGALIAVF FIGFAVWYWT IRDGTQVFSP KKEKPHTIDE
ETVPFRSTEK PLLRTISTQT LEGRRSRREP SIRGAASADD IMNHPPNAAS GTPPPGYASK
ERPQARRSSG YHEKDSSSEE NLRSAHDEDS SSERSLATSD GQVINGRTDI V
//
