ID K7WX36_9NOST Unreviewed; 501 AA.
AC K7WX36;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=prolycopene isomerase {ECO:0000256|ARBA:ARBA00012419};
DE EC=5.2.1.13 {ECO:0000256|ARBA:ARBA00012419};
GN ORFNames=ANA_C12463 {ECO:0000313|EMBL:AFW95186.1};
OS Anabaena sp. 90.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Anabaena.
OX NCBI_TaxID=46234 {ECO:0000313|EMBL:AFW95186.1, ECO:0000313|Proteomes:UP000010101};
RN [1] {ECO:0000313|EMBL:AFW95186.1, ECO:0000313|Proteomes:UP000010101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=90 {ECO:0000313|EMBL:AFW95186.1};
RX PubMed=23148582; DOI=10.1186/1471-2164-13-613;
RA Wang H., Sivonen K., Rouhiainen L., Fewer D.P., Lyra C., Rantala-Ylinen A.,
RA Vestola J., Jokela J., Rantasarkka K., Li Z., Liu B.;
RT "Genome-derived insights into the biology of the hepatotoxic bloom-forming
RT cyanobacterium Anabaena sp. strain 90.";
RL BMC Genomics 13:613-613(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene;
CC Xref=Rhea:RHEA:30971, ChEBI:CHEBI:15948, ChEBI:CHEBI:62466;
CC EC=5.2.1.13; Evidence={ECO:0000256|ARBA:ARBA00000004};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- PATHWAY: Carotenoid biosynthesis; lycopene biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004900}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane
CC {ECO:0000256|ARBA:ARBA00004258}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004258}.
CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC CrtISO subfamily. {ECO:0000256|ARBA:ARBA00005855}.
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DR EMBL; CP003284; AFW95186.1; -; Genomic_DNA.
DR RefSeq; WP_015080342.1; NC_019427.1.
DR AlphaFoldDB; K7WX36; -.
DR STRING; 46234.ANA_C12463; -.
DR KEGG; anb:ANA_C12463; -.
DR PATRIC; fig|46234.3.peg.2775; -.
DR eggNOG; COG1233; Bacteria.
DR HOGENOM; CLU_019722_4_1_3; -.
DR OrthoDB; 544714at2; -.
DR Proteomes; UP000010101; Chromosome chANA01.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046608; F:carotenoid isomerase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016117; P:carotenoid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR014101; CrtISO.
DR InterPro; IPR045892; CrtISO-like.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR NCBIfam; TIGR02730; carot_isom; 1.
DR PANTHER; PTHR46313; -; 1.
DR PANTHER; PTHR46313:SF3; PROLYCOPENE ISOMERASE, CHLOROPLASTIC; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Isomerase {ECO:0000313|EMBL:AFW95186.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000010101}.
FT DOMAIN 15..493
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 501 AA; 55361 MW; AFC7BA980ECC26B8 CRC64;
MSSELFDVII IGSGIGGLVT ATQLAAKGAK VIVFESYLIP GGSAGYFQSQ GYTFDVGASM
IFGMGNKGTT NLLTRALDAV NVNLETIPDS VQIHYHLPNG LDLKIDRDYE KFLQNLIAYF
PQEAKGIRRF YDECQKVFNC LNNIELLSLE EPKYLLRVFL KNPLACLGLA KYLPLNVGEV
ARKYIQDPQL LKFIDIECYC WSVVPADMTP MINAGMVFSD RHYGGVNYPR GGVGKIAEKL
VTGLAQLGGE IKYQARVTKI ITKQGKAVGV QLANGQVYYG KKIVSNATRW DTFTKLLPAK
KMPVKEKNWQ QRYIKSPSFL SLHIGVKSSV LPLGTECHHI LLTDWQEMTT ATGTIFVSIP
TLLDPDLAPP GYHIIHAFTP DWISNWQGLS ESEYADKKEI AAGQIIDRLE AIFPGLNAGL
DYLEIGTPRT HRRFLGRIDG TYGPIPKRKL SGLLGMPFNR TVIPNLYCVG DSTFPGQGVN
AVAFSGFACA HRIGVDLQLR K
//
