ID   K7YBY9_HELPX            Unreviewed;      1305 AA.
AC   K7YBY9;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Vacuolating cytotoxin autotransporter {ECO:0000256|ARBA:ARBA00017817};
GN   ORFNames=HPAKL117_04255 {ECO:0000313|EMBL:AFX91251.1};
OS   Helicobacter pylori Aklavik117.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1055531 {ECO:0000313|EMBL:AFX91251.1, ECO:0000313|Proteomes:UP000010079};
RN   [1] {ECO:0000313|EMBL:AFX91251.1, ECO:0000313|Proteomes:UP000010079}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Aklavik117 {ECO:0000313|EMBL:AFX91251.1};
RX   PubMed=25883278;
RA   Kersulyte D., Bertoli M.T., Tamma S., Keelan M., Munday R., Geary J.,
RA   Veldhuyzen van Zanten S., Goodman K.J., Berg D.E.;
RT   "Complete Genome Sequences of Two Helicobacter pylori Strains from a
RT   Canadian Arctic Aboriginal Community.";
RL   Genome Announc. 3:0-0(2015).
CC   -!- FUNCTION: Induces vacuolation of eukaryotic cells. Causes ulceration
CC       and gastric lesions. {ECO:0000256|ARBA:ARBA00002940}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP003483; AFX91251.1; -; Genomic_DNA.
DR   RefSeq; WP_015085944.1; NC_019560.1.
DR   KEGG; hpya:HPAKL117_04255; -.
DR   PATRIC; fig|1055531.3.peg.875; -.
DR   HOGENOM; CLU_261143_0_0_7; -.
DR   Proteomes; UP000010079; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.130; Autotransporter beta-domain; 1.
DR   InterPro; IPR005546; Autotransporte_beta.
DR   InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR   InterPro; IPR003842; Vacuolating_cytotoxin.
DR   Pfam; PF03797; Autotransporter; 1.
DR   Pfam; PF02691; VacA; 1.
DR   PRINTS; PR01656; VACCYTOTOXIN.
DR   SMART; SM00869; Autotransporter; 1.
DR   SUPFAM; SSF103515; Autotransporter; 1.
DR   PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE   4: Predicted;
KW   Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   DOMAIN          1033..1305
FT                   /note="Autotransporter"
FT                   /evidence="ECO:0000259|PROSITE:PS51208"
FT   REGION          339..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          841..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1305 AA;  141060 MW;  E1A60F90B25F7A35 CRC64;
     MELQQTHRKI NRPIISLALV GALIGTELGA NTPNDPIHSE SRAFFTTVLI PAIVGGIATG
     TAVGTVSGLL SWGLKQAEQA NKTPDKPDKV WRIQAGRGFN NFPNKQYDLY KSLLSSKIDG
     GWDWGNAARH YWVKDGQWNK LEVGMQNAVG TYNLSGLINF TGGDLDVNMQ KATLRLGQFN
     GNSFTSFKDS ADRTTRVNFD AKNILIDNFL EINNRVGSGA GRKASSTVLT LKSSEKITSR
     ENAEISLYDG ATLNLVSSSN HSVDLYGKVW MGRLQYVGAY LAPSYSTINT SKVVGEMNFR
     HLAVGDQNAA QAGIIANKKT NIGVLDLWQS AGLSIIAPPE GGYESKTKDN PKNDTQKTEI
     QPTQVIDGPF AGAKDTVVNI FRLNTKSDGT LKAGGFKASL STNAAHLNIG EGGINLSNQA
     SGRSLLVENL TGNITVEGAL RVNNQVGGSA VAGSSANFEF KAGEDTNNAT ATFNNDIHLG
     KAVNLRVDAH TAYFNGNIYL GKSTNLKVNG HSAHFKNIDA SKSDNGLNTS ALDLSGVTDK
     VNINKLTTAA TNVSIKNFDI KELVVTTRVQ SFGQYTIFGE NIGDKSRIGV VSLQTGYSPA
     YSGGVTFKSG KKLVIDEIYH APWNYFDARN VTDVEINKKI LFGAPGYIAG KTGLMFNNLT
     LNSNASMDYG KDLDLTIQGH FTNNQGVMNL FVQDGRVATL NAGHQASMIF NNVVDSATGF
     YQPLIKINNA QNLTKNKEHV LVKARNIDYN LVGVQGASYD NISASNTNLM EQFKERLALY
     NNNNRMDICV VRNTDDIKAC GMAIGNQAMV NNPDSYKYLI GKAWKNTGIS KTANNTTIAV
     NLGKNSTPTE NGGNTTDLPK NTTNKARFAS YALIKNAPFA HYNATPNLVA INKHDFGTIE
     SVFELANRSK DIDTLYASSG AQGRDLLQTL LIDSHNAGYA RTMIDATSAN EITKQLNEAN
     SALNDIASLD HKTSSLQTLS LSNAMILNSR LVNLSRRHTN NIDSFAKRLQ ALKGQRFASL
     ESAAEVLYQF APKYEKPTNV WANAIGGASL NNGGNASLYG TSAGVDAYLN GEVEAIVGGF
     GSYGYSSFNN QANSLNSGAN NTNFGVYSRI FANQHEFDFE AQGAIGSDQS SLNFKSALLQ
     DLNQSYNYLA YSAAARASYG YDFAFFRNAL VLKPSVGVSY NHLGSTNFES NSQLVALKNG
     ASSQHLFNAS ANVEARYYYG DTSYFYMNAG VLQEFANFGS SNAVSLNTFR VNVARNPLNT
     HARVMMGGEL QLAKEVFLNL GFIYAHNLIS NAGHFASNLG MRYSF
//