ID K7ZEJ8_MEGSC Unreviewed; 285 AA.
AC K7ZEJ8;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 22-FEB-2023, entry version 24.
DE RecName: Full=phosphoribosylformylglycinamidine cyclo-ligase {ECO:0000256|ARBA:ARBA00013047};
DE EC=6.3.3.1 {ECO:0000256|ARBA:ARBA00013047};
DE Flags: Fragment;
GN Name=gart {ECO:0000313|EMBL:AFY04921.1};
OS Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC Phoridae; Megaseliini; Megaselia.
OX NCBI_TaxID=36166 {ECO:0000313|EMBL:AFY04921.1};
RN [1] {ECO:0000313|EMBL:AFY04921.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21402926; DOI=10.1073/pnas.1012675108;
RA Wiegmann B.M., Trautwein M.D., Winkler I.S., Barr N.B., Kim J.W.,
RA Lambkin C., Bertone M.A., Cassel B.K., Bayless K.M., Heimberg A.M.,
RA Wheeler B.M., Peterson K.J., Pape T., Sinclair B.J., Skevington J.H.,
RA Blagoderov V., Caravas J., Kutty S.N., Schmidt-Ott U., Kampmeier G.E.,
RA Thompson F.C., Grimaldi D.A., Beckenbach A.T., Courtney G.W., Friedrich M.,
RA Meier R., Yeates D.K.;
RT "Episodic radiations in the fly tree of life.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:5690-5695(2011).
RN [2] {ECO:0000313|EMBL:AFY04921.1}
RP NUCLEOTIDE SEQUENCE.
RA Caravas J., Friedrich M.;
RT "Shaking the Diptera tree of life: performance analysis of nuclear and
RT mitochondrial sequence data partitions.";
RL Syst. Entomol. 38:93-103(2013).
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004686}.
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DR EMBL; KC178425; AFY04921.1; -; Genomic_DNA.
DR AlphaFoldDB; K7ZEJ8; -.
DR UniPathway; UPA00074; UER00129.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 1.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 1.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR036921; PurM-like_N_sf.
DR InterPro; IPR004733; PurM_cligase.
DR PANTHER; PTHR10520:SF12; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3; 1.
DR PANTHER; PTHR10520; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED; 1.
DR Pfam; PF02769; AIRS_C; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 23..169
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFY04921.1"
FT NON_TER 285
FT /evidence="ECO:0000313|EMBL:AFY04921.1"
SQ SEQUENCE 285 AA; 31079 MW; 4AAA5FDC660B59F1 CRC64;
AGYCVGVLEE GRSIFPNSHK YEDGDFIIGL PSSGLHCGGL EQVHAIIERS KDLMAKLQQP
AEFGNKSALL AQEILAPTKT YVKEVLPLIR NKQLKAVGNV SSCLQDAIKK ILPSGYGAQI
SFENVNLPEI YGWLHGPLNI SENSFLENFN CGVGMVLIAS KSNANEIVKS IPGSSVIGFL
KKNSNNITYR NFHEVLMKAS AHFEKDTGAK IEIIKSEKPV AIKNSVENLL KENSKYENLI
LTQSGKRLTK IPAKYEEPIL VIGTDGVGTK IKIAQQTEIN STVGI
//
