ID K8YCY5_9LEPT Unreviewed; 632 AA.
AC K8YCY5;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 2.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Nucleoside-diphosphate sugar epimerase {ECO:0000313|EMBL:EKT87385.2};
GN ORFNames=LSS_07224 {ECO:0000313|EMBL:EKT87385.2};
OS Leptospira santarosai serovar Shermani str. LT 821.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=758847 {ECO:0000313|EMBL:EKT87385.2, ECO:0000313|Proteomes:UP000035800};
RN [1] {ECO:0000313|EMBL:EKT87385.2, ECO:0000313|Proteomes:UP000035800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT 821 {ECO:0000313|EMBL:EKT87385.2};
RX PubMed=23041083; DOI=10.1016/j.gene.2012.09.074;
RA Chou L.F., Chen Y.T., Lu C.W., Ko Y.C., Tang C.Y., Pan M.J., Tian Y.C.,
RA Chiu C.H., Hung C.C., Yang C.W.;
RT "Sequence of Leptospira santarosai serovar Shermani genome and prediction
RT of virulence-associated genes.";
RL Gene 511:364-370(2012).
RN [2] {ECO:0000313|Proteomes:UP000035800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT821 {ECO:0000313|Proteomes:UP000035800};
RA Chou L.-F., Chen T.-W., Ko Y.-C., Pan M.-J., Tian Y.-C., Chiu C.-H.,
RA Tang P., Hung C.-C., Yang C.-W.;
RT "Potential impact on kidney infection: a whole-genome analysis of
RT Leptospira santarosai serovar Shermani.";
RL Emerg. Microbes Infect. 3:e82-e82(2014).
CC -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC {ECO:0000256|ARBA:ARBA00007430}.
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DR EMBL; CP006695; EKT87385.2; -; Genomic_DNA.
DR RefSeq; WP_004467770.1; NZ_CP006695.1.
DR AlphaFoldDB; K8YCY5; -.
DR STRING; 758847.LSS_07224; -.
DR GeneID; 29740335; -.
DR KEGG; lst:LSS_07224; -.
DR Proteomes; UP000035800; Chromosome II.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003869; Polysac_CapD-like.
DR PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR Pfam; PF13727; CoA_binding_3; 1.
DR Pfam; PF02719; Polysacc_synt_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 285..569
FT /note="Polysaccharide biosynthesis protein CapD-like"
FT /evidence="ECO:0000259|Pfam:PF02719"
SQ SEQUENCE 632 AA; 71182 MW; D6F46FCD3F324345 CRC64;
MLGRWNRRMW IFPLDLLFMG ISYFLAHWIR FESFVFLTPP ERFFTSLIIV ITVRAGVFIL
SDIYRSIWVY ASIHDLVEII KVTLLSSLIS TTALLFYNRF EQLSRMVPVL DTLLLLSFLC
IRSFSWRVFR DQYILKKSKE EGLPTLILGA GKIGATLLSE IRRHNELKLN PIGFLDDNVQ
KIGAHIQGVP ILAKIDQAEQ MINRFGVKQV IIAISNPDGK LISRLIRSFE NTDVKFKILP
SLGSLFFDSP KLNQLREVQV EDLLGRPVVD LEVESIRSYL KGKSILITGA GGSIGSELCR
QVAVFEPSRI LLLDSAETPL YEIEYELGKK LQGQNIELVP IVADIKNLSR VSSVFEKHSP
EVVFHSAAYK HVPMMEVNPT EAVMNNVLGT KNISDISRIS GVERFVLIST DKAVNPVNIM
GASKRAAELY LQHISRETKT KFITVRFGNV LGSNGSVIPR FREQIANGGP VTVTHPDVIR
YFMTIPEATQ LVLQAGSMGE CGEIFILEMG EPVKILNLAE EMIRLCGLRP HVDIPIQFTG
LRPGEKLFEE LLLDLEGIKK THHPKIKIAA PLENQEVTTF VARFNELLAA GRTNKDKDIF
LAFKALVPEY KIHGDYLNEA VESVSDRNLK NG
//
