ID K9EX72_9LACT Unreviewed; 387 AA.
AC K9EX72;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=SIS domain-containing protein {ECO:0000259|PROSITE:PS51464};
GN ORFNames=HMPREF9698_00600 {ECO:0000313|EMBL:EKU93805.1};
OS Alloiococcus otitis ATCC 51267.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Alloiococcus.
OX NCBI_TaxID=883081 {ECO:0000313|EMBL:EKU93805.1, ECO:0000313|Proteomes:UP000009875};
RN [1] {ECO:0000313|EMBL:EKU93805.1, ECO:0000313|Proteomes:UP000009875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51267 {ECO:0000313|EMBL:EKU93805.1,
RC ECO:0000313|Proteomes:UP000009875};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Alloiococcus otitis ATCC 51267.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-
CC phosphate + NH4(+); Xref=Rhea:RHEA:47680, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:71674, ChEBI:CHEBI:138150;
CC Evidence={ECO:0000256|ARBA:ARBA00029292};
CC -!- SIMILARITY: Belongs to the SIS family. AgaS subfamily.
CC {ECO:0000256|ARBA:ARBA00007748}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKU93805.1}.
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DR EMBL; AGXA01000014; EKU93805.1; -; Genomic_DNA.
DR RefSeq; WP_003777249.1; NZ_JH992958.1.
DR AlphaFoldDB; K9EX72; -.
DR STRING; 883081.HMPREF9698_00600; -.
DR PATRIC; fig|883081.3.peg.600; -.
DR eggNOG; COG2222; Bacteria.
DR HOGENOM; CLU_012520_0_0_9; -.
DR OrthoDB; 9779207at2; -.
DR Proteomes; UP000009875; Unassembled WGS sequence.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR CDD; cd05010; SIS_AgaS_like; 1.
DR CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR InterPro; IPR035466; GlmS/AgaS_SIS.
DR InterPro; IPR035464; SIS_AgaS.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR PANTHER; PTHR32502:SF3; D-GALACTOSAMINE-6-PHOSPHATE DEAMINASE AGAS-RELATED; 1.
DR PANTHER; PTHR32502; N-ACETYLGALACTOSAMINE PERMEASE II COMPONENT-RELATED; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51464; SIS; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000009875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..197
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
FT DOMAIN 221..367
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 387 AA; 42919 MW; E67E65521EED8A81 CRC64;
MFNKTDQELK DLGADITTRE IKQQPALWEE VIQDFETNGE YYANFLSTIK DRHDHTRVIF
TGAGTSAFVG ESIKEYLNKV EGEGKLSFEA IATTDLVATP EYYLKEDVPT VLVSFARSGN
SPESVAAVNV ADKIVKDLYH ITITCSKEGK LAQAAEKSDD NLLILQPELS NDQGFAMTGS
YTCMALSALF LFDPTDLSQK IDWARQIVKL GGQVIDREDE IADLVSGNFN RVVYLGGANF
FGLAKESQLK ILELTAGQIA TQYETPLGFR HGPKSFVNEE TVVILFATND AYTRQYEEDI
MNEVYHDKIA NQVLSVSTKK LDHDAKQFVL DSDLEVPDAY LVLPYVILGQ TVSLHTAVKV
GNKPDTPSPT GTVNRVVQGV VIYDYDK
//
